Council of Scientific and Industrial Research

Sun Pharmaceutical Industries Limited

Tarun Kumar Singh

Suman Preet Singh Khanuja

Rajendra Singh Bhakuni

Atul Prakash Kahol

Amit Tewari

Mohan Prasad

Madan Mohan Gupta

Ram Thaimattam

Sudeep Tandon

Ramkinkar Santra

Suman P S Khanuja

Sundeep Tandon

The present invention relates to a dapagliflozin-citric acid co-crystal, processes for its preparation, and its use for the treatment of type 2 diabetes mellitus. A dapagliflozin citric acid co-crystal. The dapagliflozin citric acid co-crystal of claim, characterized by X-ray powder diffraction peaks having d-spacing values at about 3.89, 3.90, 4.01, 4.35, 5.77, and 5.80.

Co-crystal of dapagliflozin with citric acid

The present invention provides a novel process for the preparation of bacosides enriched fraction in a non-hygroscopic form the extract of , the said process comprising the steps of drying freshly harvested herb in a hot air oven at 37-42&deg; C., powdering and sieving the dried herb to obtain powder of 30-40 mesh size, defatting the powdered herb with hexane in a modified soxhlet extractor, extracting the defatted powdered herb with acetone, again extracting the same herb with methanol to obtain an extract containing bacosides, concentrating the extract to one twentieth of its original volume under reduced pressure, gradually adding the concentrated extract to acetone for precipitating the bacosides, filtering the bacosides in a Nutsche type vacuum filter, dissolving the crude bacoside mass into 2-10 parts water, extracting the bacoside solution with n-butanol to selectively transfer the bacosides to the solvent phase, separating and concentrating the solvent phase under vacuum to obtain semi-dry mass, dissolving the semi dried mass into 2-10 parts water, adding and stirring 1-5% of &bgr;-cyclodextrin to stabilize the bacosides, spray drying the stabilized bacoside solution by maintaining hot air temperature at 90-110&deg; C., to obtain a stable free flowing fraction of rich in bacosides.

Process for the preparation of a extract rich in bacosides from the herb Bacopa monniera

The present invention provides a method for the preparation of arteether from artemisinin in one pot in just about 4 hours comprising reduction of artemisinin into dihydroartemisinin by less quantity of sodium borohydride in ethanol at room temperature in the presence of a novel polyhydroxy catalyst, acylation of dihydroartemisinin in the presence of an acid catalyst, extraction of arteether from an aqueous reaction mixture using 1% ethyl acetate in n-hexane followed by workup and purification of the impure arteether to yield 80-86% (w/w) pure alpha, beta arteether.

Single pot conversion of artemisinin into arteether

The present invention relates to an improved method for the preparation of Artemether. Artemether prepared from the process is useful for the treatment of uncomplicated, severe complicated and multi drug resistant malaria.

Single pot conversion of artemisinin into artemether

The present invention provides a single pot process for the preparation of artesunic acid from artemisinin involving reduction followed by esterification of the reduced product at room temperature.

Growing community of inventors

Lucknow, India

Tarun Kumar Singh