Massachusetts Institute of Technology

King Fahd University of Petroleum and Minerals

Tarun Kumar Jain

Rohit Nandkumar Karnik

Muataz Ali Atieh

Tahar Laoui

Suman Bose

Michael S H Boutilier

Sean C O'Hern

Nicolas G Hadjiconstantinou

Doojoon Jang

Peter A Carr

Carlos Andres Aguilar

Two-dimensional material based filters, their method of manufacture, and their use are disclosed. In one embodiment, a membrane may include an active layer including a plurality of defects and a deposited material associated with the plurality of defects may reduce flow therethrough. Additionally, a majority of the active layer may be free from the material. In another embodiment, a membrane may include a porous substrate and an atomic layer deposited material disposed on a surface of the porous substrate. The atomic layer deposited material may be less hydrophilic than the porous substrate and an atomically thin active layer may be disposed on the atomic layer deposited material.

Mitigating leaks in membranes

Devices and methods integrate nanopore and microfluidic technologies for recording molecular characteristics of individual molecules such as, for example, biomolecules. Devices comprise a first substrate comprising a microchannel, a second substrate comprising a microchannel, the second substrate positioned below the first substrate, and a membrane having a thickness of about 0.3 nm to about 1 nm and comprising at least one nanopore, the membrane positioned between the first substrate and the second substrate, wherein a single nanopore of the membrane is constructed and arranged for electrical and fluid communication between the microchannel of the first substrate and the microchannel of the second substrate. To mitigate the effect of errors that occur during de novo DNA synthesis, longer DNA molecules are typically synthesized from shorter oligonucleotides by polymerase construction and amplification (PCA), or by other methods.

Nanofluidic sorting system for gene synthesis and pcr reaction products

Growing community of inventors

New York, NY, United States of America

Tarun Kumar Jain