Kyorin Pharmaceutical Co., Ltd.

Taro Sato

Masahiro Nomura

Yasumichi Fukuda

Yasushi Kohno

Yoshikazu Asahina

Masanori Takadoi

Masaya Takei

Kyoko Okada

Hideyuki Fukuda

Hiroyuki Ebisu

Haruaki Kurasaki

To provide a novel mutilin derivative having a substitution at the 14-position, which is a novel mutilin analogue exhibiting a potent and broad antimicrobial action against Gram-positive bacteria and Gram-negative bacteria including various drug-resistant bacteria, and which is expected to be useful as an agent for treating infectious diseases. A mutilin derivative represented by the following general formula (1): or a pharmaceutically acceptable addition salt thereof.

Mutilin derivative having heterocyclic aromatic ring carboxylic acid structure in substituent at 14-position

Provided herein are aminoquinolones of formula I and compositions containing the compounds, wherein formula I is The compounds and compositions provided herein are useful in the amelioration or treatment of GSK-3 inhibitors mediated diseases.

7-cycloalkylaminoquinolones as GSK-3 inhibitors

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Tochigi, Japan

Taro Sato