Meiji Seika Kaisha, Ltd.

Merck + Co., Inc.

Other

Meiji Seika Co., Ltd.

Maiji Seika Kaisha Ltd.

Meuji Seika Kaisha Ltd.

Neiji Seika Kaisha, Ltd.

Taro Niida

Shigeharu Inouye

Takashi Tsuruoka

Takashi Shomura

Hiroshi Watanabe

Shoji Omoto

Shunzo Fukatsu

Yujiro Yamada

Takemi Koeda

Seiji Shibahara

Yasushi Murai

Shigeharu Inoue

Michio Kojima

Yasuaki Ogawa

Uichi Shibata

Yasumitsu Kondo

Tadashi Wakazawa

Katsuyoshi Iwamatsu

Tsuneo Okonogi

Fumio Kai

Hiroyasu Asaoka

Tetsuro Watanabe

Mitsugu Hachisu

Eiichi Akita

Tomizo Niwa

Yasuharu Sekizawa

Shinji Miyado

Kazuo Saito, Deceased

Burton G Christensen

Masao Koyama

Nobuto Minowa

Shigeo Seki

Takashi Hisamatsu

Kazunori Ohba

Chuhei Nojiri

Kuniomi Matsumoto

Yuzo Kazuno

Osamu Itoh

Keinosuke Miyauchi

Hitoshi Goi

Toyoaki Kawasaki

Atsuyuki Satoh

Sadaaki Mase

Satoshi Imai

Koji Watanabe

Hitoshi Ikeda

Takahiro Ishii

Masaji Sezaki

Kunitaka Tachibana

Norio Ezaki

Takeo Miyazawa

Tetsutaro Niizato

Shokichi Nakajima

Osamu Makabe

Shoichi Amano

Shingo Uchida

Kazuko Mizutani

Bunzo Nomiya

Shunzo Futkatsu

Tsuneo Okonogy

Kunikazu Totsukawa

Singo Uchida

Shigeharu Inoje

Masashi Miyamoto

Keizo Shimomura

Kazuo Saito

Mitsugu Ito

Shigeharo Inouye

Triiodoallyl- or iodopropargyl-substituted tetrazole compounds which are prepared by reacting substituted tetrazole compound with reactive derivatives of corresponding triiodoallyl alcohol or iodopropargyl alcohol or by iodinating propargyltetrazole compounds, as well as antibacterial and antifungal compositions for medicinal, agricultural and industrial fields which contain as active ingredient said tetrazole compounds.

Iodoallyl and iodopropargyl substituted tetrazoles and anti-microbial

The subject invention includes a 1-oxa-1-dethia-cephalosporin compound represented by the general formula (1) ##STR1## wherein R.sup.1 is a group of the formula: ##STR2## where R.sup.5 is a methyl group, an ethyl group, a carboxymethyl group or a 2-carboxy isopropyl group, or R.sup.1 is a group of the formula: ##STR3## where R.sup.6 is a hydrogen atom, a 4-ethyl-2,3-dioxopiperazine-1-yl group, a 3,4-dihydroxy phenyl group or a 5- and 6-membered heterocyclic radical having 2 ring nitrogens as the sole hetero substituent in the ring and having at least one hetero group on the carbon adjacent to the ring nitrogens.

1-oxa-1-dethia-cephalosporin compounds and antibacterial agent

Triiodoallyl- or iodopropargyl-substituted heterocyclic aromatic compounds which can be prepared by reacting unsubstituted- or substituted nitrogen-containing heterocyclic compounds with corresponding iodine containing alcohol reactive derivatives in the presence of a base in an inert organic solvent. These new heterocyclic aromatic compounds have remarkable antibacterial and antifungal activities and are useful as antibacterial and antifungal agents in medicinal, agricultural and industrial fields.

Disclosed is a process for preparing antibiotic 1-oxadethiacephalosporins via diazo-species I: ##STR1## wherein: A is acyl; R.sup.1 is H or OCH.sub.3 ; and R.sup.2 is a protecting group.

Process for the production of antibiotic 1-oxadethiacephalosporins, and

This invention relates to 1-oxa-1-dethia-cephalosporins which are useful as anti-biotics.

1-Oxa-1-dethia-cephalosporin derivatives

Disclosed is a novel process for preparing [(3-amino-3-carboxy)-propyl-1]phosphinic acid derivatives, comprising reacting an alkylalkylphosphonyl halide with a vinylmagnesium halide to form a vinylphosphinic acid derivative, and reacting the vinylphosphinic acid derivative with a Shiff's base to form the aimed product. Also disclosed is a novel intermediate compound formed during the course of the above process, which compound has the general formula: ##STR1## (wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are as defined in the specification).

Phosphinic acid esters and process for preparing the same

Disclosed is a novel process for optically active [(3-amino-3-carboxy)propyl-1]phosphinic acid derivatives, which comprises reacting a Shiff's base with a derivative of vinylphosphinate in the presence of a base, and subjecting the resulting compound to hydrolysis to form the optically active [(3-amino-3-carboxy)propyl-1]phosphinic acid derivatives as either [L-(3-amino-3-carboxy)propyl-1]phosphinic acid derivatives or [D-(3-amino-3-carboxy)propyl-1]phosphinic acid derivatives.

Process for preparing optically active

New 1-Oxadethiacephalosporins having a 3-loweralkyl thio group, and antibacterial compositions containing the same.

1-Oxadethiacephalosporin compound and antibacterial agent containing the

Processes for the production of antibiotic 1-oxadethiacephalosporins

Disclosed are compounds having the following general formula: ##STR1## wherein n is an integer of 1 or 2; R.sup.1 is an amino group when n is 2, or an amino group or a hydroxyl group when n is 1; and R.sup.2 is a hydroxyl group when n is 1, or a hydroxyl group or a group of the formula ##STR2## when n is 2; and microbiological process for producing the same. The compounds are useful as precursors for raising the production rate of SF-1293 substance. Some of the compounds are also useful as intermediates for synthesis of 2-amino-4-(hydroxy)(methyl)phosphinoylbutyric acid and the SF-1293 substance.

Phosphorus-containing compounds and process for producing the same

2-Amino-4-(hydroxy)phosphinoylbutyryl-L-alanyl-L-alanine.

A new polymeric compound, MF-300, is provided, which possesses a specific protective activity against bacterial infections caused particularly by Pseudomonas aeruginosa. The compound is derived from the reaction of ribostamycin with crotonoyl chloride followed by concentration of the reaction product and by subsequent recovery therefrom of a fraction having a range of molecular weights of 10,000.about.100,000 when measured by ultrafiltration method.

Polymeric compound, MF-300, with protective activity against bacterial

Novel cephalosporin derivatives having formulae (V) and (III): ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.8 and A are defined as in the specification.

Cephalosporin derivatives

5-Substituted picolinic acid derivatives represented by the formula (I): ##STR1## wherein R.sub.1 represents a straight or branched chain halogen-substituted alkyl group having 2 to 6 carbon atoms or a substituted phenyl group having the formula ##STR2## wherein R.sub.3 and R.sub.4, which may be the same or different, each represents a hydrogen atom, a halogen atom, a lower alkyl group, a lower alkoxy group, a nitro group, an amino group, an N-alkyl-substituted amino group, an acylamino group, an acetyl group, an acyloxy group, a hydroxy group or a halogen-substituted alkyl group or R.sub.3 and R.sub.4, when taken together, represent a polymethylene chain; and R.sub.2 represents an --OM group wherein M represents a hydrogen, sodium, potassium, calcium, aluminium or magnesium atom, a straight or branched chain or cyclic alkoxy group having 1 to 6 carbon atoms, an aminoalkoxy group, a phenoxy group, a substituted phenoxy group, a 5-indanyloxy group, an acyloxyalkyloxy group having the formula ##STR3## wherein R.sub.5 represents a hydrogen atom or a methyl group and R.sub.6 represents a lower alkyl group having 1 to 6 carbon atoms, a phenyl group or a substituted phenyl group, or an amino group represented by the formula ##STR4## wherein R.sub.7 and R.sub.8, which may be the same or different, each represents a hydrogen atom, a lower alkyl group, or a phenyl group which are useful as anti-hypertensive agents, a process for preparing the above 5-substituted picolinic acid derivatives, and anti-hypertensive compositions containing the same.

5-Substituted picolinic acid derivatives and an anti-hypertensive

5-Alkoxy-picolinic esters represented by the formula (I): ##STR1## wherein R represents an alkyl group having 1 to 6 carbon atoms and R.sub.1 represents an unsubstituted phenyl group; a phenyl group substituted with one or more of an alkyl group having 1 to 4 carbon atoms or an acetyl group; a phthalidyl group; an alkoxyalkyl group wherein the alkyl moiety and the alkoxy moiety each has 1 to 4 carbon atoms; an alkoxyalkoxyalkyl group wherein the alkyl moiety and the alkoxy moiety each has 1 to 4 carbon atoms; an indanyl group; or an acyloxyalkyl group having the formula ##STR2## wherein R.sub.2 represents a hydrogen atom or a methyl group and R.sub.3 represents an alkyl group having 1 to 5 carbon atoms (such as a methyl, n-propyl, isobutyl, t-butyl, etc., group), an alkoxy group having 1 to 4 carbon atoms, a phenyl group, a phenyl group substituted with one or more of an alkyl group having 1 to 4 carbon atoms, an alkoxy group having 1 to 4 carbon atoms or a halogen atom (such as chlorine, bromine, iodine, etc., atom) or an aralkyl group wherein the alkyl moiety has 1 to 3 carbon atoms, which are useful as anti-hypertensive agents, a process for preparing 5-alkoxy-picolinic esters, and anti-hypertensive compositions containing the 5-alkoxy-picolinic esters.

5-Alkoxy-picolinic esters and anti-hypertensive composition containing

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Yokohama, Japan

Taro Niida