Eisai Company, Limited

Eisai R&d Management Co., Ltd.

Taro Hihara

Richard S Clark

Masanobu Shinoda

Fumiyoshi Matsuura

Takashi Inoue

Kazuto Yamazaki

Eita Emori

Sadakazu Miyashita

Shunji Kasai

Hideki Yoshitomi

Hitoshi Harada

Kaya Ohashi

The present invention provides novel carboxylic acid derivatives useful as an insulin sensitizer, a salt thereof or a hydrate of them, and a medicament comprising the derivative as the active ingredient. Specifically, it provides a carboxylic acid derivative represented by the following formula (I): (wherein Y, L, X, T, Z, U, M and W are defined in the specification) and a salt thereof, and ester thereof or a hydrate of them.

Carboxylic acid derivative, a salt thereof or an ester of them, and medicament comprising it

Carboxylic acid compound or salt or hydrate thereof useful as insulin sensitizer, represented by the formula wherein Rrepresents hydrogen, hydroxyl, halogen, carboxyl, or Calkyl, L represents single bond or C-alkylene, C-alkenylene, or C-alkynylene, M represents single bond or C-alkylene, C-alkenylene, or C-alkynylene, T represents single bond, or C-alkylene, C-alkenylene, or C-alkynylene, W represents carboxyl, represents single bond, X represents single bond, oxygen, &#x2014;NRCQO&#x2014;, &#x2014;OCQNR&#x2014;, &#x2014;CQNRO&#x2014;, ONRCQ&#x2014;, &#x2014;QSO&#x2014;, or &#x2014;SOQ&#x2014;, Y represents 5- to 14-membered aromatic group, and ring Z represents 5- to 14-membered aromatic group.

Carboxylic acid derivative and salt thereof

The present invention provides a novel compound having an excellent PPAR agonist action. More specifically, it provides a compound represented by the following formula, a salt thereof, an ester thereof or a hydrate of them. Wherein a, b and c are the same as or different from one another and each represents 0 to 4; Rto Rare the same as or different from one another and each represents a hydrogen atom, a hydroxyl group, a cyano group, a halogen atom, etc.; represents a single bond or a double bond;

Cyclic compound and PPAR agonist

The present invention provides a novel carboxylic acid derivative, a salt thereof or a hydrate of them which is useful as an insulin sensitizer, and a medicament comprising the derivative as the effective ingredient. More specifically, it provides a carboxylic acid compound represented by the formula (I), a salt thereof or a hydrate of them. In the formula, Ar represents a 6- to 14-membered aromatic ring group which may have at least one substituent; R, R, R, R, R, R, Rand Rare the same as or different from each other and each represents a hydrogen atom, a halogen atom, a hydroxyl group, a Calkyl group or a Calkoxy group; X represents an oxygen atom or a methylene group; Y represents a group represented by the formula (II) or (III): (wherein Z represents a group represented by the formula (IV): (wherein R, R, Rand Rare the same as or different from each other and each represents a hydrogen atom, a halogen atom, a hydroxyl group, a Calkyl group or a Calkoxy group)); m is 0 or 1; and n is 0 or 1.

Carboxylic acids

The present invention provides a medicament comprising a benzene compound useful as an insulin sensitizer, a salt thereof or a hydrate of them and a derivative of them as the active ingredient. Specifically, it provides a benzene compound represented by the following formula, a salt thereof or a hydrate of them. In the formula, X represents 1) a Caryl group which may have one or more substituents or 2) a 5- to 10-membered heteroaryl group which may have one or more substituents; Y represents a group represented by the formula: (in the above formulae, R, Rand Rare the same as or different from one another and each represents a hydrogen atom, a halogen atom, a Calkyl group, a Calkoxy group, or a Ccycloalkyl group) etc.; Z represents a group represented by the formula: (in the formula, m represents an integer of 0 to 2; R, Rand Rare the same as or different from one another and each represents a hydrogen atom, a halogen atom, a Calkyl group, a Calkoxy group, a Ccycloalkyl group, a halogenated Calkyl group, a halogenated Calkoxy group etc.); and R, R, Rand Rare the same as or different from one another and each represents a hydrogen atom, a halogen atom, a Calkyl group, a Calkoxy group, a Ccycloalkyl group etc.

Growing community of inventors

Ibaraki, Japan

Taro Hihara