Kowa Company Limited

Nissan Chemical Industries Limited

Taro Aoki

Katsutoshi Miyosawa

Toru Miura

Kimiyuki Shibuya

Tadaaki Ohgiya

Koichi Yamazaki

Ayumu Okuda

Toshiharu Arai

Haruki Shibata

Toru Yokoyama

Yusuke Sasaki

Junji Yamaguchi

Yasunobu Yoshinaka

Hiroyuki Yamazaki

Fumiyasu Sato

Takashi Maejima

The present invention provides a method for treatment of diabetes, comprising administering a pitavastatin, and in combination therewith, enalapril or a salt thereof.

Method for the treatment of diabetes

The present invention is directed to a triglyceride-lowering agent, exhibiting excellent triglyceride-lowering effect and a hyperinsulinemia-ameliorating agent. The triglyceride-lowering agent and hyperinsulinemia-ameliorating agent are characterized by containing a pitavastatin compound, and amlodipine or a salt thereof.

Triglyceride-lowering agent and hyperinsulinism-ameliorating agent

A compound represented by the following general formula (I), wherein R, R, R, Rand Rrepresent hydrogen atom, a halogen atom, a lower alkyl group and the like, Rrepresents an alkyl group, a cycloalkyl group and the like, Rand Rrepresent hydrogen atom, a lower alkyl group, a (lower cycloalkyl)(lower alkyl) group and the like, Rrepresents hydrogen atom, a halogen atom, a lower alkoxy group and the like, Rand Rrepresent hydrogen atom, a lower alkyl group, a lower alkoxy group, a halo(lower alkyl) group and the like, and A represents a heterocyclic ring constituted by 6 to 10 atoms, which has potent inhibitory activity on cholesterol ester transfer protein (CETP). 

Substituted pyrimidine compounds and their utility as CETP inhibitors

The present invention provides a medicament exhibiting an excellent nerve cell death inhibitory action. The present invention relates to a nerve cell death inhibitor comprising a pitavastatin and donepezil or a salt thereof in combination.

Nerve cell death inhibitor

A hypertriglyceridemia therapeutic agent made up of a synergistically effective blood-triglyceride decreasing amount of a combination of a pitavastatin and eicosapentaenoic acid (EPA), or an ester thereof.

Hyperlipemia therapeutic agent

A compound represented by the following general formula (I) or a salt thereof, or a solvate thereof: (wherein R, R, R, Rand Rare the same or different, and represent hydrogen atom, a halogen atom, a lower alkyl group etc., R, Rand Rare the same or different, and represent hydrogen atom, a halogen atom, a lower alkyl group etc., Rand Rare the same or different, and represent hydrogen atom, a lower alkyl group, a (lower cycloalkyl)(lower alkyl) group etc., and Rrepresents hydrogen atom, a halogen atom, a lower alkoxy group, a (lower alkyl)thio(lower alkoxy) group, a (lower alkyl)sulfinyl(lower alkoxy) group, a (lower alkyl)sulfonyl(lower alkoxy) group etc.), which has potent inhibitory activity on CETP.

Pyrimidine compound having benzyl(pyridylmethyl)amine structure and medicament comprising the same

A compound represented by the following general formula (I), wherein R, R, R, Rand Rrepresent hydrogen atom, a halo(lower alkyl) group, cyano group and the like, Rrepresents an alkyl group, a cycloalkyl group and the like, R, R, Rand Rrepresent hydrogen atom, a halogen atom, a lower alkyl group, a halo(lower alkyl) group and the like, Rand Rrepresent hydrogen atom, a lower alkyl group, a (lower cycloalkyl) (lower alkyl) group and the like, and Rrepresents hydrogen atom, a halogen atom, a lower alkoxy group and the like, which has potent inhibitory activity on cholesterol ester transfer protein (CETP). 

Pyrimidine compound having dibenzylamine structure and medicament comprising the same

This invention relates to a method for treating thrombosis by combined administration of a pitavastatin with aspirin.

Method for treating thrombosis

Provided is a method for treating hyperlipidemia or hypercholesterolemia, which comprises administering effective doses of ezetimibe and pitavastatin or a salt or lactone derivative thereof.

Method for treating hyperlipidemia

The present invention relates to a hyperlipemia therapeutic agent comprising pitavastatins and eicosapentaenoic acid or an ester derivative thereof as effective ingredients. According to the present invention, a type IIb and type IV hyperlipemia therapeutic agent having an excellent effect of lowering the cholesterol and triglyceride in blood is provided.

Growing community of inventors

Tokorozawa, Japan

Taro Aoki