Abbott Laboratories Corporation

Tariq Ghayer

Boris Labkovsky

Jochen G Salfeld

Michael White

Richard W Dixon

Michael Roguska

John A Mankovich

Alexander Robert Duncan

Simon Mark Brocklehurst

Celia Patricia Shorrock

Julia Elizabeth Thompson

Simon Nicholas Lennard

Antibodies that bind human interleukin-18 (hIL-18) are provided, in particular antibodies that bind epitope(s) of human IL-18. The antibodies can be, for example, entirely human antibodies, recombinant antibodies, or monoclonal antibodies. Preferred antibodies have high affinity for hIL-18 and neutralize hIL-18 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Method of making and method of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hIL-18 and for inhibiting hIL-18 activity, e.g., in a human subject suffering from a disorder in which hIL-18 activity is detrimental.

Antibodies that bind IL-18 and methods of inhibiting IL-18 activity

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Holliston, MA, United States of America

Tariq Ghayer