The Nottingham Trent University

Tarik Regad

An antibody or antigen-binding fragment that binds human endothelial protein C receptor (hEPCR) and neutralizes, reduces or interferes with at least one activity of hEPCR, in which (a) the antibody or antigen-binding fragment has a heavy chain variable region (HCVR) with at least 80% identity to a sequence selected from SEQ ID NO: 1, 3, 5 and 7, and/or a light chain variable region (LCVR) with at least 80% identity to a sequence selected from SEQ ID NO: 2, 4, 6 and 8, and/or (b) the antibody or antigen-binding fragment has a heavy chain variable region (HCVR) selected from SEQ ID NO: 1, 3, 5 and 7 with 10 or fewer conservative amino acid substitutions and/or a light chain variable region (LCVR) selected from SEQ ID NO: 2, 4, 6 and 8 with 10 or fewer conservative amino acid substitutions, is disclosed.

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Nottingham, United Kingdom

Tarik Regad