University of Colorado

Intermune, Inc.

Suvica, Inc.

Tarek Sammakia

Steven Wade Andrews

Yutong Jiang

Pierre Martin

Timothy S Kercher

Bin Wang

Gan Zhang

Scott D Seiwert

Lawrence M Blatt

Weidong Liu

Paul Nichols

Michael Lyon

April L Kennedy

Andreas Schumacher

C Todd Eary

Robert J Kaus

Tin Tin Su

Mara N Gladstone

Bradley Barnett

Bradley R Barnett

The present invention is directed at bouvardin analogs arid related compounds for the treatment of disorders including cancer. Provided herein are bouvardin analogs and related compounds, pharmaceutical compositions and kits comprising at least one bouvardin analog or related compound, and methods for treating disorders including cancer. In some aspects the compounds inhibit translation elongation at the ribosome. The compounds are used in combination with radiation therapy or with known chemotherapeutic compositions.

Bouvardin derivatives and therapeutic uses thereof

Bourvadin derivatives and therapeutic uses thereof

The embodiments provide compounds of the general Formulae I through general Formula VIII, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition.

Macrocyclic inhibitors of hepatitis C virus replication

Growing community of inventors

Boulder, CO, United States of America

Tarek Sammakia