Bayer Cropscience Ag

Bayer Intellectual Property Gmbh

Bayer Aktiengesellschaft

Taraneh Farida

Martin Littmann

Albert Schnatterer

Michael Esser

Rafael Warsitz

Hubertus Stakemeier

Berndt Maiwald

Christian Funke

Jan Vermehren

Winfried Etzel

Kyra Larissa Pabst

Nicolas Henck

Ali Sanli

Reiner Fischer

Norbert Lui

Olga Malsam

Stefan Lehr

Ulrich Görgens

Heinz Kehne

Thomas Auler

Wahed Ahmed Moradi

Guido Bojack

Volker Brehme

Stefanie Rinker

Juergen Ludwig

Reiner Rosellen

Daniel Hartmann

Stefan Beeck

Jürgen Ludwig

Nioclas Henck

The present invention relates to a novel, one-stage method for preparing and isolating 3,4-dichloro-N-(2-cyanophenyl)-5-isothiazolecarboxamide (isotianil), which has microbicidal and plant-fortifying (host defence inducer) properties. In the method according to the invention, the amount of waste from the production process (e.g. solvent) is significantly reduced. The product is provided in high yield and purity (minimal amount of by-products and impurities). Compared to existing preparation methods, the method according to the invention has the advantage of low corrosiveness and high yield and high selectivity.

Method for producing 3,4-dichloro-N-(2-cyanophenyl)-5-isothiazolecarboxamide

The present invention relates to a novel process for preparing and isolating 3,4-dichloro-N-(2-cyanophenyl)-5-isothiazolecarboxamide (Isotianil), which can be used as an active compound with microbicidal properties, wherein the amount of waste materials&#x2014;e.g. solvents and diluents&#x2014;is significantly reduced and the process meets the requirements of industrial scale production, in particular that it provides the product in high yield, high purity, i.e. minimum amount of by-products and impurities, and can be carried out with tolerable corrosivity in industrial scale metal, in particular stainless steel, vessels or Cr&#x2014;Ni&#x2014;Mo alloy pressure filters or centrifuges.

Process for preparing 3,4-dichloro-n-(2-cyanophenyl)-5-isothiazolecarboxamide

The present invention relates to novel methods for preparing cis-alkoxy-substituted spirocyclic 1-H-pyrrolidine-2,4-dione derivatives and also to novel intermediates and starting compounds, which are passed through or used in the method according to the invention.

Method for preparing cis-alkoxy-substituted spirocyclic 1-H-pyrrolidine-2,4-dione derivatives

The invention relates to a method for producing compounds of formula (Ia), in particular to a method for producing N-[4-(cyclopropylcarbamoyl)phenylsulfonyl]-2-methoxybenzamide.

Method for producing acylsulfamoylbenzamides

Process for preparing compound of formula (Ia) 

Process for preparing 4[[(benzoyl)amino]sulphonyl]benzoyl chlorides and preparation of acylsulphamoylbenzamides

The present invention relates to a novel process for preparing cis-alkoxy-substituted spirocyclic phenylacetylamino acid esters and cis-alkoxy-substituted spirocyclic 1H-pyrrolidine-2,4-dione derivatives, and also to novel intermediates and starting materials which are produced and/or used in the process according to the invention.

Process for preparing cis-alkoxy-substituted spirocyclic phenylacetylamino acid esters and cis-alkoxy-substituted spirocyclic 1H-pyrrolidine-2,4-dione derivatives

Process for preparing 4-[[(benzoyl)amino]sulphonyl]benzoyl chlorides of the formula (II). 

Process for preparing cis-alkoxy-substituted spirocyclic phenylacetylamino acid esters and cis- alkoxy-substituted spirocyclic 1H- pyrrolidine-2,4-dione derivatives

The invention relates to novel 2-acyloxypyrrolin-4-ones of the formula (I) in which A, B, G, W, X, Y and Z have the meaning given above,to a plurality of processes and intermediates for their preparation, and to their use as pesticides and/or herbicides. The invention also relates to selective herbicidal compositions comprising, firstly, the 2-acyloxypyrrolin-4-ones and, secondly, a crop plant compatibility-improving compound. The present invention furthermore relates to the boosting of the action of crop protection compositions comprising, in particular, 2-acyloxypyrrolin-4-ones, through the addition of ammonium salts or phosphonium salts and optionally penetrants, to the corresponding compositions, to processes for producing them and to their application in crop protection as insecticides and/or nematicides and/or acaricides and/or for preventing unwanted plant growth.

2-acyloxy-pyrrolin-4-ones

The present invention relates to a multi-stage method for preparing alkali metal salts of specific 4-hydroxy-2-oxo-2,5-dihydrofuran-3-carboxylic esters of the formula (I), in which M and Rare as defined in the description,which proceeds from malonic ester and does not require isolation of intermediates.

Multistage process for preparing alkali metal salts of specific 4-hydroxy-2-oxo-2,5-dihydrofuran-3-carboxylic esters

Process for preparing sodium or potassium salts of 4-hydroxy-2-oxo-2,5-dihydrofuran-3-carboxylic esters, comprising the reaction of a malonic ester with potassium hydroxide to give the corresponding malonic ester potassium salt of the formula (III) which is then reacted further with a chloroacetic ester to give a compound of the formula (V) followed by a ring closure reaction in which the compound of the formula (V) is reacted with a sodium or potassium alkoxide of the formula ZORwhere R, R, Rand K are each as defined in the description.

Process for preparing sodium salts or potassium salts of 4-hydroxy-2-oxo-2,5-dihydrofuran-3-carboxylate

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Pulheim-Geyen, Germany

Taraneh Farida