Johns Hopkins University

Tara Williamson

Gregory J Riggins

Avadhut D Joshi

Renyuan Bai

Verena Staedtke

Ren-Yuan Bai

Mebendazole is an antiparasitic drug with over 40 years of safe use. Recently mebendazole was repurposed for glioblastoma therapy. Three polymorphs of mebendazole exist, but the relative polymorph content for existing drugs varies, and the therapeutic anti-cancer relevance of the different polymorphs was unknown. As an oral drug mebendazole polymorph C is a superior form, and it reaches the brain and brain tumors in effective concentrations. Efficacy is further improved by combining mebendazole with a P-glycoprotein inhibitor. Mebendazole may also be used for therapy of other cancers, as well as a chemo-preventative agent.

Growing community of inventors

Baltimore, MD, United States of America

Tara Williamson