Amgen Inc.

Amgen Research (munich) Gmbh

Kite Pharma, Inc.

Tara Arvedson

Jackie Zeqi Sheng

Grace Ki Jeong Lee

Barbra Sasu

Xiao-juan Bi

Tobias Raum

Claudia Blümel

Elisabeth Nahrwold

James Rottman

Christoph Dahlhoff

Irwin Chen

Julie Bailis

Gregory Dyas

Sandra Ross

Thomas Charles Boone

Jed Wiltzius

Lawren Wu

Jochen Pendzialek

Johannes Brozy

Alice Bakker

Ruben Alvarez Rodriguez

Aaron George Winters

Keegan Cooke

Mitsuru Haniu

Joachim Wahl

The present invention provides bispecific antibody constructs characterized by comprising a first domain binding to MUC17, a second domain binding to an extracellular epitope of the human and theCD3ε chain and optionally a third domain, which is a specific Fc modality. Moreover, the invention provides a polynucleotide, encoding the antibody construct, a vector comprising this polynucleotide, host cells, expressing the construct and a pharmaceutical composition comprising the same.

Bispecific antibody construct directed to MUC17 and CD3

The present invention relates to an antibody construct comprising a domain which binds to Claudin 18.2 (CLDN18.2) and another domain which binds to CD3. Moreover, the invention provides a polynucleotide encoding the antibody construct, a vector comprising said polynucleotide and a host cell transformed or transfected with said polynucleotide or vector. Furthermore, the invention provides a process for producing the antibody construct of the invention, a medical use of said antibody construct and a kit comprising said antibody construct.

Antibody constructs for CLDN18.2 and CD3

Antigen binding molecules, chimeric receptors, and engineered immune cells are disclosed in accordance with the invention. The invention further relates to vectors, compositions, and methods of treatment and/or detection using the antigen binding molecules and engineered immune cells.

Chimeric receptors and methods of use thereof

Compositions for treating disorders of iron homeostasis are provided. More particularly, anti-ferroportin antibodies, compositions containing such antibodies, corresponding nucleic acids, vectors and host cells, and methods of making such antibodies are provided.

Ferroportin antibodies and methods of use

The invention relates to purified, correctly folded hepcidin, antibodies that bind hepcidin, and methods of making and using such materials. Also provide are methods of treated hepcidin-related disorders.

Hepcidin, hepcidin antagonists and methods of use

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Simi Valley, CA, United States of America

Tara Arvedson