Jawaharlal Nehru Centre for Advanced Scientific Research

UniversitÉde Strasbourg

The Rockfeller University

University of Mysore

Tapas Kumar Kundu

Ruthrotha Selvi Bharatha Vikru

Karanam Balasubramanyam

Mantelingu Kempegowda

Hari Kishore Annavarapu

Philip A Cole

Govindaraju Thimmaiah

Robert G Roeder

Ehab M Khalil

Venkatesh Swaminathan

Anne-Laurence Boutillier

Raymond E Soccio

Ontario D Lau

Vankatesh Swaminathan

Karthigeyan Dhanasekaran

Arun Kumar Manna

Debabrata Maity

Snehajyoti Chatterjee

Muthusamy Eswaramoorthy

Pushpak Mizar

Chantal Mathis

Jean-Christophe Cassel

Romain Neidl

Mohankrishna Dalvoy Vasudevarao

Vedamurthy Bhusainahalli Maheshwarappa

Eswaramoorthy Muthusamy, Sr

Dinesh Jagadeesan

Swapan Kumar Pati

Mohammed Arif

Gopinath Kodaganur Srinivasachar

Kempegowra Mantelingu

Radhika Ashish Varier

Nanjundaswamy Shivananju

Badi Sri Sailaja

The present invention is in relation to a composition including nanosphere and histone acetyltransferase (HAT) activator. The nanosphere is carbon nanosphere (CSP) which is intrinsically fluorescent and the HAT activator is N-(4-Chloro-3-trifluoromethyl-phenyl)-2-n-propoxy-benzamide. The N-(4-Chloro-3-trifluoromethyl-phenyl)-2-n-propoxy-benzamide is covalently conjugated with the carbon nanosphere. The present invention further relates to a process for obtaining a composition including carbon nanosphere and Histone acetyltransferase (HAT) activator [N-(4-Chloro-3-trifluoromethyl-phenyl)-2-n-propoxy-benzamide]. The composition is capable of crossing blood brain barrier and inducing histone acetylation in brain. Further, the composition is capable of increasing neurogenesis, as well as improving long-term memory formation. The composition manages pathological conditions to a subject in need thereof, such as aging-related, neurodegenerative diseases (Alzheimer's in particular), neurological disorders, depression or other kinds of diseases in which increased HAT activity, neurogenesis and/or memory improvement would benefit.

Nanosphere-histone acetyltransferase (HAT) activator composition, process and methods thereof

The present invention provides solution to the problem involved in delivery of active molecules to nucleus. More particularly, the invention provides intrinsically fluorescent and inherently surface functionalized carbon nanospheres which are non-toxic. Also, these carbon nanospheres [CSP] were adsorbed with CTPB [CSP-CTPB] and the adsorbed CSP-CTPB are permeable to cells with nuclear targeting ability. In addition, the present invention provides a composition, a process to prepare the composition comprising CSP with adsorbed active/therapeutic molecules. Further, the instant invention provides a method for delivering active molecules inside a cell nucleus.

Intrinsically fluorescent carbon nanospheres and a process thereof

Compounds that selectively bind to copper ions in a sample and methods of preparing and using the compounds are described. Disclosed herein are planar julolidine based compounds that display characteristic absorbance in the visible and near-infrared (NIR, 700-1000 nm) region in the presence of copper ions. Methods to detect Cuions by fluorometry and colorimetry are disclosed.

Julolidine conjugates and methods for their preparation and use

The present invention relates to compounds of structural formula I as site-specific inhibitors of histone methyltransferase, where Rand Ris &#x2014;OCHor &#x2014;OH, Rand Ris &#x2014;OH or &#x2014;OAc; a process of isolating compound of structural formula Ia, where Rand Ris &#x2014;OCH, Rand Ris &#x2014;OH; a process of preparation of compound of structural formula Ib, where Rand Ris &#x2014;OCH, Rand Ris &#x2014;OAc; a process of preparation of compound of structural formula Ic, where Rand Ris &#x2014;OH, Rand Ris &#x2014;OH; and use of compounds of structural formula I for manufacture of a medicament for management of cancer and/or disease conditions in a subject in need thereof.

Site-specific inhibitors of histone methyltransferase (HMTASE) and process of preparation thereof

Site-specific inhibitors of histone methyltransferase [HMTase] and process of preparation thereof

The invention provides the use of certain benzoic acid and benzamide compounds as modulators of enzymes histone acetyltransferases, which are involved in gene expression and cancer and also use of such compounds in the treatment of diseases due to defects in gene regulation predominantly cancer. 

Modulators (inhibitors/activators) of histone acetyltransferases

Disclosed are compounds of the formulae: and method of using the compounds to treat cancer, AIDS, HIV infection, and asthma.

Histone acetyltransferase inhibitors, especially those that are differentiate between p300 and PCAF histone acetyltransferase; also therapeutic processes comprising their administration to humans.

Inhibitors of histone acetyltransferases (HATs) and uses thereof

Growing community of inventors

Karnataka, India

Tapas Kumar Kundu