University of Illinois

Tapas K DasGupta

John M Pezzuto

Darrick S H L Kim

Darrick S Kim

Lydia Ling-Indeck

Konrad Marc Kuzmanoff

Mary Lou Schmidt

Compositions and methods are disclosed for treating melanoma wherein a betulinic acid derivative is the active compound in the composition to be administered. The compositions are optionally applied topically is inserted therefor.

Method and composition for selectively inhibiting melanoma

A composition and method of preventing or inhibiting tumor growth, and of treating malignant melanoma, without toxic side effects are disclosed. Betulinic acid or a betulinic acid derivative is the active compound of the composition, which is topically applied to the situs of tumor.

A composition and method of preventing or inhibiting tumor growth, and of treating malignant cancers without toxic side effects are disclosed. Betulinic acid or a betulinic acid derivative is the active compound of the composition.

Method and composition for treating cancers

A composition and method of inhibiting tumor growth and treating malignant melanoma without toxic side effects are disclosed. Betulinic acid or a betulinic acid derivative is the active compound of the composition, which is topically applied to the situs of tumor. Betulinic acid is obtained by the steps of preparing an extract from the stem bark of Ziziphus mauritiana to mediate selective cytotoxic profile against human melanoma in the subject panel of human cancer cell lines, conducting a bioassay-directed fractionation based on the profile of biological activity using cultured human melanoma cells as the monitor, and obtaining betulinic acid.

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River Forest, IL, United States of America

Tapas K DasGupta