Nanjing Hanxin Pharmaceutical Technology Co., Ltd.

Hohe University

Tao Yang

Haoning Zhang

Jundong Meng

Feifei Wu

Xudong Zhou

Youwei Qin

Xin Zheng

Zhenya Li

Pengfei Shi

Lina Chou

Polypeptide preparation methods of preparing high-purity ACTH (human sequence) or analogue and large-scale preparation method thereof are described. The main steps include: amino acids are coupled from the C-terminal to the N-terminal by Fmoc solid-phase synthesis method to obtain the crude ACTH (human sequence) or analogue peptidyl-resin with protective groups, wherein the reaction temperature of C-15 peptide synthesis is 40-60° C. After cleavage and precipitation, the crude product of ACTH (human sequence) or analogue is obtained, and then the high-purity product is obtained by liquid chromatography. The chromatographic purity of ACTH (human sequence) or analogue prepared by the invention is more than 99%, the stability is good, and the yield of the target peptide is ≥63%.

High-purity adrenocorticotropic hormone analogue and a large-scale preparation method thereof

The invention discloses a microwave rain attenuation law based artificial rainfall experimental method with an adjustable link length, including the following steps of: 1) designing and calculating rainfall intensities in different return periods to form an experimental rainfall process, and simulating artificial rainfall by using an artificial rainfall hall; 2) building a corner reflector to dynamically adjust the microwave link length; 3) installing an experimental microwave device, and selecting a microwave link with a specific microwave frequency band as an experimental link; 4) using a self-recording rain gauge to obtain measured data on the experimental link under different rainfall intensities; and 5) according to the measured data, obtaining a whole process of the experimental rainfall intensity change, and analyzing and calculating the microwave rain attenuation law.

Microwave rain attenuation law based artificial rainfall experimental method with adjustable link length

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Nanjing, China

Tao Yang