Chinese Academy of Sciences

Zhe Jiang Jutai Pharmaceutical Co., Ltd.

Shanghai Zhigen Pharmaceutical & Technology Co., Ltd.

Tao Xue

Bin Guo

Yushe Yang

Shi Ding

Wenke Wang

Jing Huang

Hong Luo

Chunsheng Tan

Kaisheng Jin

Hongbo Liu

Yongsheng Xiong

Xiangdong Su

Daqiao Hu

Li He

Yuanfa Ding

Danning Li

Jian Huang

Yilang Chen

Yong Li

Gang Li

The present invention relates to an aromatic compound and a preparation method therefor and the use thereof. Specifically, disclosed are a compound as shown in the following general formula (I), or a tautomer, an enantiomer, a diastereomer or a racemate thereof or a mixture thereof, or a pharmaceutically acceptable salt thereof. Also disclosed are a method for preparing the above compound and the use of same in the treatment of nervous system diseases.

Aromatic compound and preparation method therefor and use thereof

The present invention relates to the field of a pharmaceutical compound, and more specifically, relates to a new oxazolidone compound, an enantiomer, a diastereoisomer and a raceme thereof, and a mixture thereof, and a pharmaceutically acceptable salt thereof, a preparation method thereof, an application thereof as a bioactive substance in a drug. The compound in the present invention has strong anticoagulant activity, does not affect the activity of thrombin, and can reduce the risk of hemorrhage. A pharmacokinetics experiment shows that the compound in the present invention further has good metabolic characteristics, and has a far better oral bioavailability than a positive contrastive agent rivaroxaban.

Oxazolidone compound, preparing method and application thereof

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Shanghai, China

Tao Xue