Colgate Palmolive Company

Boston University

Periodontix, Inc.

Other

Peak Degrees Holdings LLC

Tao Xu

Harsh Mahendra Trivedi

Michael Prencipe

Frank G Oppenheim

Linh Fruge

James Richard Brown

Davide Miksa

F Donald Roberts

Virginia Monsul Barnes

Peter Spacciapoli

Kimberlee Panaligan

Cortney L Worrell

Wei Wang

Phillip M Friden

Abdul Gaffar

Ying Yang

Dale S Scherl

Susan M Herles

Suman Kumar Chopra

James G Masters

Prithwiraj Maitra

Sayed Ibrahim

Lori H Szeles

André M Morgan

Chanda Macias

Christopher Pesek

Michael Saffaie

Yanan Hu

William Xiques

Ramachandra Shastry

Emi Shimizu

Nicola C Partridge

Andre Michelle Morgan

Michael Principe

Oral care compositions containing a stannous salt and sodium tripolyphosphate are provided where stannous tripolyphosphate ionic intermediates comprise less than about 1% of the compositions. Tetrasodium pyrophosphate, a methylvinyl ether-maleic anhydride copolymer and/or a silica oral polishing agent may be added for further efficacy. In a single phase blend, the oral care composition may be effectively limited to comprise less than about 10% water. In a dual-phase blend, a mixture having the stannous salt in a first phase and the sodium tripolyphosphate in a second phase may be generated from a dual chamber storage tube (with each phase provided from a separate chamber) immediately prior to dental care usage.

Stannous salt and sodium tripolyphosphate oral care compositions and methods

A height adjustable chair includes a user support platform assembly, and posterior and anterior leg assemblies. The user support platform assembly includes first, second, and third platform portions, and a pair of pivot mechanisms. The posterior and anterior leg assemblies include laterally opposed upper leg portions, laterally opposed lower leg portions, and locking mechanisms for locking the lower leg portions in extended relation relative to the upper leg portions. The pivot mechanisms pivotally attach to first platform portion and the posterior leg assembly. The anterior leg assembly is pivotally attached to the posterior leg assembly, the first platform portion, and the third platform portions. The first support platform supports a user thereupon. The anterior and posterior leg assemblies enable the user to vary the height of the first support platform relative to a support surface.

Height adjustable chair

A glute bridge exercise apparatus enables a user to variously exercise glute muscle groups, and includes a first and second platform assemblies. The first platform assembly includes a first platform portion, a first peripheral frame, and a pair of first extension legs. The pair of first extension legs are telescopically receivable in and extensible from laterally opposed frame portions of the first peripheral frame. The second platform assembly includes a second platform portion, a second peripheral frame, and a platform support portion. A proximal frame end is pivotally attached to the first platform assembly adjacent the pair of first extension legs. The platform support portion is pivotally attached to a distal frame end and enables a user to adjust an angle of inclination of the second platform portion relative to the first platform portion for positioning the user between the first and second platform portions for variously exercising muscle groups.

Glute bridge exercise apparatus

A lower back exercise apparatus exercises or imparts laterally and upwardly directed movements into a user's lower back when seated thereupon. The lower back exercise apparatus includes a lower base assembly, an upper seat assembly, and a motor assembly. The lower base assembly includes an upper, laterally concave base surface. The upper seat assembly includes a lower, laterally convex seat surface and an upper seat surface. The upper seat assembly is laterally ridable upon and movable relative to the lower base assembly. The motor assembly is drives a laterally directed, cylindrical arc length trajectory of the upper seat assembly relative to the lower base assembly. The concave and convex surfacing have a common radius of curvature with a common fulcrum point spatially located adjacent an upper portion of a user's lumbar spinal region. Lateral flexion is thus imparted into a user's lower back when a user is seated thereupon.

Lower back exercise apparatus

The present invention discloses novel uses of specific menthol-derivative compounds of Formula 1, and compositions thereof, for methods of providing oral and systemic health care benefits, and methods of up-regulating or down-regulating periodontal disease metabolites: Formula 1 wherein, X is an oxygen atom or an NH radical; and R is an unsubstituted or substituted aryl or aliphatic radical. In some embodiments, the oral and systemic health care benefits include biofilm anti-attachment, anti-inflammation, anti-oxidant, anti-bone loss, and anti-microbial benefits. In some embodiments, the periodontal disease metabolites correspond to healthy and/or diseased oral status and allow differential diagnosis of oral health. 

Menthol-derivative compounds and use thereof as oral and systemic active agents

Described herein are compositions comprising a MMP-13 inhibitor, and methods of using the same.

Oral care compositions and methods

Oral care compositions containing a stannous salt and sodium tripolyphosphate are provided where stannous tripolyphosphate ionic intermediates comprise less than about 1 of the compositions. Tetrasodium pyrophosphate, a methylvinyl ether-maleic anhydride copolymer and/or a silica oral polishing agent may be added for further efficacy. In a single phase blend, the oral care composition may be effectively limited to comprise less than about 10% water. In a dual-phase blend, a mixture having the stannous salt in a first phase and the sodium tripolyphosphate in a second phase may be generated from a dual chamber storage tube (with each phase provided from a separate chamber) prior to dental care usage.

The present invention encompasses an oral composition containing an anti-adhesion agent, preferably a cysteine protease and most preferably ficin. In another aspect, the cysteine protease is in combination with one or more ingredients, such as antibacterial agent and surfactant. The anti-adhesion agent mitigates interaction between a subject oral cavity and plaque-forming materials.

Oral compositions for prevention and reduction of bacterial adhesion to oral surfaces

Oral care compositions containing a stannous salt and sodium tripolyphosphate are provided where stannous tripolyphosphate ionic intermediates comprise less than about 1% of the compositions Tetrasodium pyrophosphate, a methylvinyl ether-maleic anhydride copolymer and/or a silica oral polishing agent may be added for further efficacy. In a single phase blend, the oral care composition may be effectively limited to comprise less than about 10% water. In a dual-phase blend, a mixture having the stannous salt in a first phase and the sodium tripolyphosphate in a second phase may be generated from a dual chamber storage tube (with each phase provided from a separate chamber) immediately prior to dental care usage.

An efficacious antibacterial and anti-inflammatory oral composition is provided having an active ingredient combination comprising one or more active compounds from an extract ofand an extract of hops. Preferably, the active compounds fromextract comprise honokiol and magnolol, and the active compounds from hops extract comprise hexahydrogenated beta acids. The oral composition can be in the form of a mouth rinse or dentifrice, including toothpaste, gels, powders, confectionaries, lozenges, animal products, and the like. Methods of making and using the oral composition are also provided.

Oral care compositions containing compounds from magnolia and hops extracts

The present invention encompasses an oral treatment composition containing an anti-adhesion agent, preferably a cysteine protease and most preferably ficin. In another aspect, the cysteine protease is in combination with one or more ingredients, such as antibacterial agent and surfactant. The anti-adhesion agent mitigates interaction between a subject oral cavity and plaque-forming materials.

Oral treatment compositions containing an anti-adhesion agent, antibacterial agent and incompatible compound

An oral composition for at least one or treating and inhibiting an oral inflammatory condition comprising:

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Growing community of inventors

Newton, MA, United States of America

Tao Xu