Chinese Academy of Sciences

Tianjin University

Beijing Naton Medical Technology Holdings Co., Ltd.

Accendatech

Tianjin International Joint Academy of Biotechnology & Medicine

Tao Sun

Yimin Song

Yanhe Ma

Sida Liu

Jing Min Xu

Qian Jack Liu

Chaoguang Tian

Jingen Li

Chuannan Long

Liangcai Lin

Wei Yan

Jingxiao Ji

Wenliang Sun

Jing Wang

Xueli Zhang

Yue Chen

Jing Zhao

Hongtao Xu

Cheng Yang

Qiang Zhang

Jinlei Tang

Panfeng Wang

Binbin Lian

Honggang Zhou

Huijuan Liu

Yanrong Liu

Chengyu Zhang

Xiangming Zhang

Yuan Qin

Xueshuang Jing

Qingyan Li

Guanping Dai

Zhiyuan He

Jing Xu

Qian Liu

A wearable robot for integrated fracture reduction and rehabilitation, comprising a proximal ring, a distal ring, six driving branch chains, motor driving device and manual driving device; the six driving branch chains are divided into two groups, each of them comprises a platform connecting sleeve, a sliding bearing, a bearing locking nut, a proximal Hooke hinge, an intermediate prismatic pair, a sleeve, a force sensor, and a distal Hooke hinge; one end of the driving branch chain is connected with the proximal ring by a connecting sleeve fastener, and the other end is connected with the distal ring by nut, each driving branch chain is connected with the driving devices via D-shaped shaft sleeve. The wearable robot has electric-manual dual model driving, and the branch chain can be quickly replaced during and after the operation.

Wearable robot for integrated fracture reduction and rehabilitation

The present invention discloses an automatic recognition method for spatial position and pose of parallel external fixator, including the following steps of: installing three markers on each of the two fixation rings of the parallel external fixator; obtaining 3D images of six marker balls after scanning and reconstruction by a common 3D clinical imaging system; recognizing the sphere center coordinates of the six marker balls by sphere fitting algorithm; according to the mounting configuration of the markers on the two fixation rings, establishing coordinate systems of two fixation rings and determining the spatial position and pose of the external fixator; in addition, by obtaining the 3D images of the fracture bone segments with the 3D clinical imaging system and simulating the movement of the fracture deformity correction, the adjustment schedule of the external fixator struts can be achieved.

Automatic recognition method for spatial position and pose of parallel external fixator for fracture reduction

A freely-connectable three-strut parallel orthopedic external fixator including two fixation rings and three struts, connecting holes are circumferentially and uniformly distributed on the ring surfaces of each fixation ring, each strut is provided with two driving translational pairs, a revolute pair and a spherical pair. Two fixation rings are respectively fixedly connected with the bone segments of the fracture site by using medical metal bone pins; adjusting the driving translational pairs of the six struts can achieve six DoF relative movement of the two fixation rings, thereby achieving fracture reduction. The external fixator of the present invention realizes free connection between the two fixation rings, which facilitates fixator installment; number of struts is less than the existing external fixators.

Freely-connectable three-strut parallel orthopedic external fixator

Provided are an engineered strain for synthesizing a dibasic organic acid and preparation and application of same. The engineered strain introduces or up-regulates expression of a positive regulator gene for synthesis of a dibasic organic acid, and/or down-regulates expression of a negative regulator gene for synthesis of a dibasic organic acid, as compared with the origin strain of the engineered strain, the producing capability for producing the dibasic organic acid is improved. The dibasic organic acid comprises malic acid, succinic acid, fumaric acid, oxaloacetic acid, glutaric acid, and adipic acid; the expression product of the positive regulator gene comprises aspartate aminotransferase, glutamic acid-aspartate transporter, C4-dicarboxylic acid transporter, pyruvate carboxylase and malate dehydrogenase, glucose transporter; the expression product of the negative regulatory gene comprises succinyl-CoA synthase, and malic acid-alpha ketoglutarate transporter, and the original strain comprises, and

Dibasic organic acid producing strain and preparation and application of same

A fracture reduction method and a parallel external fixator for fracture reduction for realizing the method, the fracture reduction method being used for existing six-chain ring-shaped parallel external fixators in minimally invasive fracture reduction or osteotomy of limbs. The parallel external fixator comprises two fixation rings, six struts and six markers, the fixation rings are arranged with a plurality of connecting holes, the struts are arranged with a spherical hinge, a driving joint (), a quick-mounting component and a universal hinge, the markers comprise marker balls and a pin shaft. The parallel external fixator can improve the treatment accuracy, reliability and operation convenience.

Fracture reduction method and parallel external fixator for fracture reduction

The present invention provides an application of a dimethylamino micheliolide for preparing a pharmaceutical product for treating pulmonary fibrosis.

Method for treating pulmonary fibrosis comprising application of dimethylamino micheliolide

Provided are a recombinant strain for preparing a terpenoid, and method for constructing the recombinant strain. Also provided is a recombinant bacterium 1, the recombinant bacterium 1 being a recombinant bacterium obtained in order to improve the enzymatic activity of &#x3b1;-ketoglutarate dehydrogenase inor the mutant thereof. The method for improving the enzymatic activity of &#x3b1;-ketoglutarate dehydrogenase inor the mutant thereof is replacing the original regulating element of the ketoglutarate dehydrogenase gene (sucAB) inor the mutant thereof with any of the following regulating elements: artificial regulating element M1-46, M1-37, and M1-93. Also provided are a plurality of recombinant bacteria. By improving the enzymatic activity of &#x3b1;-ketoglutarate dehydrogenase, succinic acid dehydrogenase and transaldolase therein and improving the ability of a cell to synthesize NADPH and ATP, the efficiency of the MEP pathway and the production capacity of terpenoid are improved.

Recombinant microorganism for preparing terpenoid and method for constructing recombinant microorganism

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Tianjin, China

Tao Sun