Chinese Academy of Sciences

Fudan University

Shandong Luoxin Pharmaceutical Group Stock Co., Ltd.

Shanghai Miracogen Inc

Shanghai Haihe Pharmaceutical Co., Ltd.

Shanghai Kumhosunny Plastics Co., Ltd.

Mabwell (shanghai) Bioscience Co., Ltd.

Jiangsu Mabwell Health Pharmaceutical R&d Co., Ltd.

Mabwell Bioscience Co., Ltd.

Tao Meng

Jingkang Shen

Lanping Ma

Xin Wang

Ke Yu

Wei Zhang

Ting Yu

Xuesai Zhang

Qingrou Li

Yongliang Zhang

Bing Xiong

Qing Lin

Zhiyan Du

Jian Ding

Ying Chu Wang

Meiyu Geng

Ting Zhou

Jing Ai

Minqi Xin

Zehong Miao

Xia Peng

Minghua Luo

Hongli Peng

Ying Wang

Shanshan Song

Yinchun Ji

Jianping Hu

Rui Jin

Danqi Chen

Jinpeng Pei

Yingqing Wang

Jing Al

Yuchi Ma

Yuelei Chen

Arie Zask

Lanfang Meng

Yiyi Chen

A tissue factor (TF)-targeted antibody-drug conjugate (ADC) and a method for preparing the ADC. The ADC is capable of binding to TF antigen with high specificity, and has high affinity, low immunogenicity, high cytotoxicity, and significant anti-tumor activity.

Tissue factor-targeted antibody-drug conjugate

Disclosed are a new AXL-targeting monoclonal antibody and antibody-drug conjugate. Also disclosed is a method for preparing said antibody and antibody-drug conjugate. The AXL antibody of the present invention can bind with purified human AXL protein and multiple AXL on tumor cell surface with high effectiveness and high specificity. Said humanized antibody also has high affinity and low immunogenicity. Said AXL antibody-drug conjugate has markable performance against tumors having high AXL expression.

AXL-targeting antibody, antibody-drug conjugate, preparation method therefor, and use thereof

The present disclosure provides an ultralow-glossiness, ultralow-temperature resistant ASA resin composition and preparation method thereof. The composition includes the following components in parts by weight: 20&#x2dc;60 parts of an acrylonitrile-styrene-acrylate graft copolymer, 40&#x2dc;80 parts of an acrylonitrile-styrene copolymer, 1&#x2dc;20 parts of an ultralow-glossiness, low temperature resistant modifier, and 0.1&#x2dc;5 parts of a processing aid. The ultralow-glossiness, low temperature resistant modifier includes a carrier copolymer, a fluorinated copolymer, a low-temperature flexibilizer, a coupling agent, fumed silica and an assistant. The ASA resin composition prepared by the present disclosure has an ultralow-glossiness, can be used to replace mold processing technology such leather marking and texturing, which greatly saves mold cost and processing production cost; and meanwhile it also has excellent low temperature resistance and can be applied in cases having requirements on low temperature resistance and low glossiness such as automobile parts, outdoor profiles, building materials and electrical appliances.

Ultralow-glossiness, ultralow-temperature resistant ASA resin composition and preparation method thereof

The present invention relates to dihydroquinoxaline bromodomain recognition protein inhibitor, preparation method and use thereof. The inhibitor of the present invention is compound represented by general formula (I), or stereoisomer, pharmaceutically acceptable salt, prodrug, solvate, hydrate and crystal form thereof. The definition of each substituent is as described in the description and claims. The compound represented by general formula (I) of the present invention may inhibit bromodomain recognition protein and may be used for preparing medicament which regulates the apparent state of cells and treats series of diseases and symptoms which are mediated by the bromodomain recognition protein. 

Dihydroquinoxaline bromodomain recognition protein inhibitor, preparation method and use thereof

Provided in the present invention are a di-substituted maleic amide linker conjugated to an antibody and a preparation method and use thereof. In particular, the present invention conjugates a strongly cytotoxic active substance to a biomacromolecule through a class of new linkers. The class of linkers can selectively act simultaneously with disulphide chains, so as to greatly improve the substance homogeneity of a conjugate. The conjugate prepared by the linker of the present invention has a high inhibitory activity on a cell strain expressing the corresponding antigen. Also provided is a method for preparing the above-mentioned conjugate and the use.

Di-substituted maleic amide linker for antibody drug conjugating and preparation method and use thereof

Provided is a process of synthesizing a substituted pyridine and pyrimidine compound. Particularly, provided is a method for preparing a compound of formula III via a compound of formula II', wherein the definition of each of groups is as described as the description. Compound with other methods, the method in the present invention has features of high yield and a result product being easier to separate. 

Process of synthesizing substituted pyridine and pyrimidine compound

This invention provides a class of five-member-heterocycle fused pyridine compounds as shown below in Formula (X), pharmaceutically acceptable salts or pharmaceutically acceptable solvates thereof, a method of producing the same, pharmaceutical compositions containing the compound, and use of the compounds in preparing medicament for preventing and/or treating diseases and tumors associated with abnormal protein tyrosine kinase. 

Five-member-heterocycle fused pyridine compounds, method of producing the same, and use thereof

The present invention belongs to the field of pharmaceutical Chemistry. In particular, the present invention relates to a pyridopyrimidine or pyrimidopyrimidine compound as represented by general formula (I), or an isomer thereof or a pharmaceutically acceptable salt, ester, prodrug or solvate thereof, a preparation method, a pharmaceutical composition and uses thereof in preparing a mTOR inhibitor. As a mTOR inhibitor, the compound or the pharmaceutical composition thereof can be used for treating a disease or condition due to PI3K-AKT-mTOR signalling pathway malfunction. 

Pyridopyrimidine or pyrimidopyrimidine compound, prepration method, pharmaceutical composition, and use thereof

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Shanghai, China

Tao Meng