Chinese Academy of Sciences

Zhejiang University

Leadway (hk) Limited

Airoha Technology (suzhou) Limited

Suzhou Sinovent Pharmaceuticals Co., Ltd.

Guangzhou Lixin Pharmaceutical Co., Ltd.

Hangzhou Puqiao Network Technology Co., Ltd.

Tao Liu

Yongzhou Hu

Jia Tao Li

Yubo Zhou

Xiaowu Dong

Bo Yang

Xiaobei Hu

Lei Xu

Dong Wang

Qiaojun He

Mingbo Su

Anhui Gao

Peipei Wang

Qinjie Weng

Ximing Shen

Xiaodong Wu

Chia-Lin Wang

Wenhu Zhan

Pinrao Song

Lexian Tong

Yaodong Wu

Yujun Gao

Binbin Hong

Yonghui Wang

Chunqi Li

Juan Zhou

Huanxi Ge

Wandeng Liu

Jia Li

Yan Zhu

Shiqun Wang

Yun Ye

Jiankang Zhang

A computer device includes a network interface circuit, a storage device, and a processor. The network interface circuit is used to receive a first transmission control protocol (TCP) packet from another computer device, wherein the first TCP packet include a session layer content. The storage device is used to store a program code. The processor is used to load and execute the program code to perform the following operation: computing a network speed of a network used by the computer device according to information carried by the session layer content.

Device and method for achieving improved network speed test result by preventing transmission control protocol packets from being re-transmitted

The present invention provides a 2-polysubstituted aromatic ring-pyrimidine derivative and an optical isomer thereof, or a pharmaceutically acceptable salt or solvate thereof, the compound, and an optical isomer thereof or a pharmaceutically thereof acceptable salts or solvates can be used in the preparation of anti-tumor drugs. The invention designs and synthesizes a series of novel small molecule Chk1 inhibitors by using N-substituted pyridin-2-aminopyrimidine obtained by structure-based virtual screening as a lead compound, and carries out Chk1 kinase inhibitory activity test. The experiment confirmed that said compounds possess potent anticancer activity, Chk1 kinase inhibitory activity, and are promising Chk1 inhibitors, and can be used as new cancer therapeutic drugs, which can be applied to treat solid tumors or hematologic tumors related to proliferative disease of human or animal. The 2-polysubstituted aromatic ring-pyrimidine derivatives provided by the present invention has the structure of the formula I: 

2-polysubstituted aromatic ring-pyrimidine derivatives, preparation and medical application thereof

A polyfluoro-substituted aromatic heterocyclic derivative having the structure as represented by formula I or formula I', wherein at least one of Rand Ris a fluorine atom, and at least two substituents of Rc, Rd, Re, and Rf are fluorine atoms; and an optical isomer of the derivative, or a pharmaceutically acceptable salt or solvate of the same, or a pharmaceutically acceptable salt or solvate of the optical isomer of the same. A composition containing the polyfluoro-substituted aromatic heterocyclic derivative and an application of the composition in preparing an anti-tumour medicament. The compound provides significant inhibitory effects with respect to Akt1 and demonstrates strong proliferation inhibitory activity with respect to tumour cell lines such as an ovarian cancer cell line, a colon cancer cell line, and a prostate cancer cell line. Therefore, the compound may be used as an Akt inhibitor in the medicament for treating a cell proliferation-related solid tumour or blood cancer in the human or animal body.

Polyfluoro-substituted aromatic heterocyclic derivative, pharmaceutical composition containing same, and applications thereof

Fascia gun

A 2-substituted aromatic ring-pyrimidine derivative as shown in a general formula I, and an optical isomer or a pharmaceutically acceptable salt or a solvate thereof are provided. The present invention designs and synthesizes a series of novel small molecular Chk1 inhibitors by using N-substituted pyridin-2-aminopyrimidine obtained through structure-based virtual screening as a lead compound, and carries out Chk1 kinase inhibitory activity test. The experiment confirmed that said compounds possess strong anti-cancer effect, Chk1 kinase inhibitory activity and are promising Chk1 inhibitors. The compounds can be used as new cancer therapeutic drugs, which can be applied to treat solid tumors or hematologic tumors related to proliferative disease of human or animal.

2-substituted aromatic ring-pyrimidine derivative and preparation and application thereof

A five-membered heterocyclic amide WNT pathway inhibitor having the following general structural formula: The five-membered heterocyclic amide WNT pathway inhibitor has a remarkable anti-tumor activity based on a target-based rational drug design, and can be used for the development of a new generation of Wnt pathway inhibitors, and has a great clinical application value and considerable market potential.

Five-membered heterocyclic amides WNT pathway inhibitor

Disclosed are new substituted nitrogen-containing heterocyclic derivatives represented by formula (I) as AKT inhibitors, optical isomers, pharmaceutically acceptable salts or solvates thereof, wherein the definition of R1, R2, R3, R4, R5, R6, ring A, ring C, B, Q, Y, Z and m is shown in the description for details. In addition, medicaments comprising the derivatives as active components are also disclosed, which can be useful for treating proliferative diseases, such as cancer and inflammation, especially diseases relating to AKT kinase.

Substituted nitrogen-containing heterocyclic derivatives, pharmaceutical compositions comprising the same and applications of antitumor thereof

The present invention provides an automatic encoding device including a first electrode, a second electrode, and a third electrode. The first electrode and the second electrode are connected through a connecting point, so that an electric parameter between the first electrode and the second electrode changes according to a parameter needing to be corrected. The present invention further provides a method for applying the automatic encoding device to various biosensors and a method for manufacturing the automatic encoding device. Positions and the number of contacts for connecting the automatic encoding device and a detection system are fixed. Therefore, connection sites on the detection system are effectively utilized. On the other hand, the automatic encoding device in the present invention can provide different parameter information by only changing the positions of the connecting points on the electrodes, the process is simple and stable, and the probability of human errors is reduced.

Automatic coding device, biosensor with same and manufacturing method therefor

Disclosed are a tripeptide epoxyketone compound, a preparation method thereof, and a use thereof in the preparation of anti-tumor drugs.

Tripeptide epoxyketone compound constructed by heterocycle and preparation method and use thereof

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Zhejiang, China

Tao Liu