Integratech Proteomics, LLC

The United States of America, As Represented by the Secretary, Department of Health and Human Services

University of Utah Research Foundation

National Institutes of Health

Tanya Sandrock

Robert Craigie

A Wayne Meikle

Jared M Orrock

Alan H Terry

David J Stillman

Described herein are compositions and methods for inhibiting HIV integrase activity. Also described are methods of identifying agents that inhibit HIV integrase for use in treating or preventing HIV. Also disclosed are methods of identifying agents that inhibit HIV viral mutants that are resistant to integrase inhibitors.

Inhibitors of viral integrase and methods of use

The present invention provides for methods and systems for detecting steroids. Examples of such steroids include estrogen, progesterone, androgen, testosterone, and derivatives and analogs thereof. Systems useful for carrying out the method include tripartite constructs including a DNA-binding domain, a ligand binding domain, and an activation domain. The present invention provides numerous improvements over previous diagnostic systems for detection of steroids, such advantages include that the method allows for detection of steroid analogs and derivatives, whose structures may not yet be known, the method is generally applicable to a wide variety of organisms, and numerous ligand binding domains may be used in conjunction with the present system.

Methods and compositions for detecting steroids

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Salt Lake City, UT, United States of America

Tanya Sandrock