Case Western Reserve University

Other

Tanvir Baig

Robert L Brown

Brian T Grimberg

Robert J Deissler

William A Edelstein

Tesfaye Kebede Kidane

Timothy P Eagan

Abdullah Amin

Robert Brown

Victor Taracilla

Michael Martens

A system is described herein that can be used to perform magneto-optical detection of a disease component in a test sample using magnetic nanoparticles. A concentration of magnetic nanoparticles and a concentration of bindable agents can be administered to the test sample. The magnetic nanoparticles can be configured to attach to the bindable agents. A light beam can be transmitted through the test sample to a light detector. A magnetic field gradient can be established through the test sample. If the transmitted light beam under the magnetic field gradient exhibits a variable intensity change during a time period, the disease component can be determined to exist in the test sample.

Magneto-optical detection of Lyme disease using magnetic nanoparticles

A diagnostic device is described herein that can be used to perform magneto-optical detection and discernment of crystals within a biofluid sample. A magnetic field can be applied by the diagnostic device in a direction relative to light traveling through the sample. The presence of a crystal can be determined based on the magneto-optical properties of the sample. The detected crystal can be one of two similar crystal types that may be in the biofluid sample. The two similar crystal types can exhibit different magneto-optical properties under a magnetic field in a different direction. Accordingly, the type of crystal can be discerned by applying the magnetic field in the different direction as light travels through the sample. Discernment of the type of crystal can lead to diagnosis of the particular disease condition and subsequent proper treatment of the disease condition.

Magneto-optical detection and discernment of biofluid crystals

The present invention provides an apparatus for reducing acoustic noise in a magnetic resonance imaging device including passive shielding located outside the actively shielded gradient winding elements in order to reduce the magnitude of fields that spread outside the gradient coil assembly in unwanted directions and interact with the magnet cryostat or other metallic magnet parts, inducing eddy currents that cause consequent acoustic noise. The passive shielding elements are conducting layers located on the outer radius of the cylindrical gradient coil assembly in a cylindrical magnet system, conducting layers located at the ends of the gradient coil assembly in a cylindrical magnet system, and conducting layers located inside the actively shielded gradient winding inner elements in a cylindrical magnet system. The passive shielding could also be located on separate structures that are vibrationally isolated from the magnet cryostat. The actively shielded gradient winding can also be extended to portions at the ends of the actively shielded gradient winding and further to portions inside the inner radius of the inner portion of the actively shielded gradient winding. The actively shielded gradient windings and passive shielding should be designed concurrently in order to substantially optimize the gradient linearity and reduce the eddy currents generated in metallic parts of the magnetic resonance imaging system.

Active-passive electromagnetic shielding to reduce MRI acoustic noise

Growing community of inventors

Cleveland, OH, United States of America

Tanvir Baig