Humboldt-universitaet Zu Berlin

Veb Arzneimittelwerk Dresden

Veb Fahlberg-list Chemische Und Pharmazeutische Fabriken

Tankred Schewe

Jurgen Slapke

Horst Lyr

Dieter Zanke

Thomas Strumpf

Walter Furst

Joerg Beger

Hartmut Kuehn

Samuel M Rapoport

Gunter Voigt

Hartmut Kuhn

Renate Grupe

Grupe, Renate

Gerhard Fries

Juergen Slapke

Lothar Lucke

Hans-Joachim Binte, Deceased

Reinhard Neubert

Rapoport, Samuel M

Improved bioavailability, particularly when the drug is administered orally, of the active ingredient 2-hydroxy-5-methyllaurophenoxime (HMLO) of a pharmaceutical preparation is achieved by improving the absorption of the active ingredient HMLO significantly by including bile acids in the preparation. As bile acids, it is possible to use, for example, desoxychloic acid or dehydrocholic acid or a mixture of the two in the form of their salts.

Composition and methods for providing optimum bioavailability of the

New 1-(2-hydroxylaryl)-alkane-1-on-oximes, procedure for their preparation, and their applicability to pharmaceutical preparations. One purpose is to develop 1-(2-hydroxyaryl)-alkane-1-on-oximes with desirable pharmacological properties. The new compounds of Formula I ##STR1## are characterised by pharmacologically valuable properties, in particular by anti-asthmatic, anti-anaphylactic, antiphlogistic, antihypertensive, spasmolytic, antirheumatic, and antithrombotic, potentials and are applicable in human and veterinary medicine to therapy of asthma bronchiale and other allergic diseases, various kinds of inflammatory and rheumatic diseases, and thrombosis.

1-(2-hydroxyaryl)-alkane-1-on-oximes-procedure of preparation and use in

Hydroxamic acids, pharmaceutical preparations containing the same, new .omega.(2'-naphthoxy)-alkylhydroxamic acids as well as a process for their production are disclosed. The new compounds display antiasthmatic and further pharmacologically valuable characteristics. They are prepared by reacting the corresponding carboxylic acid ester or amide with hydroxylamine or its salt under the described conditions into compounds of Formula I,

Hydroxamic acid and pharmaceutical preparations containing the same

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Berlin, Germany

Tankred Schewe