Smithkline Beecham Corporation

Other

Tania Tamson Testa

Michael R Barnes

David P Kelsell

David Malcolm Duckworth

Robert James Godden

Robert S Ames

Caretha Lee Creasy

Israel Simon Gloger

John A Feild

Jonathan Alexander Terrett

Trudy Rachel Doe

Stephen A Hughes

SPHINGLY polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilising SPHINGLY polypeptides and polynucleotides in therapy, and diagnostic assays for such.

Human sphingosine lyase polypeptides

Wnt-7 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing Wnt-7 polypeptides and polynucleotides in therapy, and diagnostic assays for such.

Human Wnt7a polypeptides

Rabbit G alpha 16 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing rabbit G alpha 16 polypeptides and polynucleotides in screening of antagonists or agonists of cells co-expressing a G-protein coupled receptor and rabbit G alpha 16.

Polynucleotide and polypeptide sequence of rabbit G-protein alpha 16

Rattus YAK1 polypeptides and polynucleotides and method for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for screening for compounds which either agonize or antagonize rattus YAK1. Such compounds are expected to be useful in treatment of human diseases, including, but not limited to osteoarthritis, osteoporosis, rheumatoid arthritis.

Compounds

Patched-2 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing Patched-2 polypeptides and polynucleotides in therapy, and diagnostic assays for such.

Patched-2 polypeptide

Wnt-7,polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing Wnt-7,polypeptides and polynucleotides in therapy, and diagnostic assays for such.

Human Wnt-7a polynucleotides

SPHINGLY polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing SPHINGLY polypeptides and polynucleotides in therapy, and diagnostic assays for such.

Polynucleotides encoding human sphingosine Lyase

Tubby 2 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing Tubby 2 polypeptides and polynucleotides in the design of protocols for the treatment of diabetes, obesity, and atherosclerosis, among others, and diagnostic assays for such conditions.

Tubby 2 polypeptides

Wnt-5b polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing Wnt-5b polypeptides and polynucleotides in therapy, and diagnostic assays for such.

Patched-2 polypeptides and polynucleotides

Wnt-3 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing Wnt-3 polypeptides and polynucleotides in therapy, and diagnostic assays for such.

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London, United Kingdom

Tania Tamson Testa