Centro De Immunologia Molecular (cim)

Tania Crombet Ramos

Gisela Maria Gonzalez Marinello

Ernesto Chico Veliz

Lisel Vina Rodriguez

Ariadna Cuevas Fiallo

Agustin Bienvenido Lage Davila

Gryssell Rodriguez Martinez

Loany Calvo Gonzalez

Arama Albisa Novo

A vaccine composition for therapeutic use thereof on cancer patients includes a chemical conjugate of human recombining Epidermic Growth Factor (hrEGF) and a combining protein P64k for performing a conjugation reaction which produces said chemical conjugate in a controlled and reproducible manner. The preferred conjugate surprisingly increases the immunogenic activity causing significant increases in the anti-EGF antibody titers in humans, and provides a vaccine preparation with more than one type of effective dose presentation which enables the immunization dose per patient to be increased, but without involving an increase in immunization frequency and/or the number of immunization sites.

Method for making a homogenous vaccine composition comprising a conjugate of EGF and 64K for the treatment of tumors

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Havana, Cuba

Tania Crombet Ramos