Olon S.p.a.

Tania Cristiano

Marco Alpegiani

Eugenio Cucchetti

Roberto Strigaro

Tamara Ines Danelli

Disclosed is a process for the synthesis of the active ingredients ospemifene and fispemifene which comprises reacting phenol 4 with an alkylating agent X&#x2014;CHCH&#x2014;Y of formula 7, wherein X is a leaving group and Y is the &#x2014;(OCHCH)OH group wherein n is zero or 1; or X and Y, taken together, represent an oxygen atom; to give ospemifene or fispemifene of formula 8. 

Process for the preparation of ospemifene and fispemifene

Disclosed is a process for the preparation of abiraterone and abiraterone acetate with high yields and purity. A key element of the method is the isolation of a crystalline intermediate that makes the process particularly suitable for implementation on an industrial scale.

Procedure for the preparation of abiraterone acetate and intermediates thereof

Disclosed is a process for the preparation of abiraterone and abiraterone acetate with high yields and purity. A key element of the method is the isolation of a crystalline intermediate that makes the process particularly suitable for implementation on an industrial scale. There is also provided a process for the production of abiraterone acetate by acetylation of abiraterone in the absence of bases or acetylation catalysts.

The invention relates to a process for the purification of crude abiraterone acetate by treatment with polymer resins in aqueous solvent. The purified product is recovered by simple concentration and filtration.

Process for the purification of abiraterone acetate

Disclosed is a method for the conversion of a compound of formula 3 to a compound 

Growing community of inventors

Milan, Italy

Tania Cristiano