Biomerieux, Inc.

Centre National De La Recherche Scientifique

Université Claude Bernard Lyon I

Hospices Civils De Lyon

Centre Hospitalier Universitaire De Nantes

Anaquant

Chu De Dijon

Tanguy Fortin

Jean-Philippe Charrier

Arnaud Salvador

Chloé Bardet

Yannick Charretier

Tiphaine Cecchini

Christelle Compagnon

Guillaume Monneret

Genevieve Choquet-Kastylevsky

Fabienne Venet

Alexandre Pachot

Karim Asehnoune

Sylvie Pons

Geneviève Choquet-Kastylevsky

Jerome Lemoine

Marilyne Dupin

Antoine Roquilly

Jordane Biarc

Hader Haidous

Jean Faivre

Jérôme Lemoine

Jéröme Lemoine

Bernard Allaouchiche

Philippe Dugourd

Aurélie Gouel-Cheron

Audrey Larue-Triolet

Chloe Bardet

A method for quantifying at least one microorganism group via at least one mass spectrometry analysis is described. The method includes at least one separation and fragmentation step. The method moreover includes a step that involves measuring the amount of at least one representative peptide or at least one protein representing the microorganism group. The at least one representative peptide or the at least one protein is obtained after the at least one separation and fragmentation step and serves as a quantification marker(s). The amount of the quantification marker(s) is directly correlatable to the amount of the at least one microorganism group.

Method for quantifying at least one microorganism group via mass spectrometry

A method for quantifying at least one microorganism group via at least one mass spectrometry analysis. The method includes at least one separation and fragmentation step. The method moreover includes a step that involves measuring the amount of at least one representative peptide or at least one protein representing the microorganism group. The at least one representative peptide or the at least one protein is obtained after the at least one separation and fragmentation step and serves as a quantification marker(s). The amount of the quantification marker(s) is directly correlatable to the amount of the at least one microorganism group.

The present invention concerns the preparation of solutions, particularly for implementing analytical methods, in particular by spectrometry, particularly for producing standard solutions which are useful, for example, for calibrating spectrometers or for implementing diagnostic methods. It allows the implementation of an easy process for preparing such standard solutions.

Soluble balls for preparing solutions

The invention relates to a method for detecting a colorectal lesion likely to evolve into invasive colorectal cancer, in a patient, by determining the presence of Liver Fatty Acid-Binding Protein (LFABP), in a biological sample of the patient, distant form the lesion.

Method for detecting a colorectal lesion

A method for predicting the risk of developing a disseminated infection in a patient admitted to intensive care having no clinical symptoms of such infection includes: determining a first dose of gelsolin G1 in a biological sample from the patient originating from a first sample taken at time T1, carried out between the day of intensive care admission and 48 hours afterward; determining a second dose of gelsolin G2 in a biological sample from the patient originating from a second sample taken at time T2, carried out two to three days after the first sampling; calculating the variation between the dose of gelsolin G2 and the dose of gelsolin G1, giving a &#x394; value; and comparing the &#x394; value to a threshold value S determined beforehand from two patient populations admitted to intensive care, one not having developed a disseminated infection and the other having developed such an infection.

Prediction of the risk of developing a disseminated infection for patients admitted to an intensive care unit

The present invention relates to a method for the quantitative detection of a target protein in a sample, in which the second-generation fragment ions are detected for providing a series of quantitative measurements, at least one of which is correlated to the amount of proteotypic peptide generated and to the amount of target protein in the sample, characterized in that the selected first-generation fragment ion having a mass (m/z)is a doubly-charged peptide having a proline and/or a histidine in position 1.

Method for quantifying proteins by mass spectrometry

A method for detecting at least one target molecule in a sample by mass spectrometry, comprising ionizing the molecules of the sample and then conducting the following steps (i) and (ii) n times, n being equal to 0, 1, 2, 3 or 4: (i) at least one ion obtained in the preceding step is selected, according to the target molecule, in a mass analyzer, and (ii) the ion thus selected is fragmented in a fragmentation cell; trapping at least two different sampled ions, when n is zero, or when n is other than zero, in a mass analyzer, the at least two ions thus trapped having a mass-to-charge ratio m/z characteristic of the target molecule; ejecting the trapped ions from the mass analyzer; and detecting the ejected ions ejected by means of a detection device. The method is characterized in that the characteristic ions are ejected simultaneously and detected simultaneously.

Method for detecting molecules through mass spectrometry

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Lyons, France

Tanguy Fortin