Advinus Therapeutics Private Limited

Impetis Biosciences Limited

Tanaji Mengawade

Bheemashankar A Kulkarni

Debnath Bhuniya

Kasim A Mookhtiar

Summon Koul

Santosh Kurhade

Kasim Mookhtiar

Yogesh Munot

Mahesh Thakkar

The present disclosure provides hetero-bicyclic compounds of formula (I), their tautomers, polymorphs, stereoisomers, prodrugs, solvates, hydrates, N-oxides, co-crystals, pharmaceutically acceptable salts, pharmaceutical compositions containing them and methods of treating conditions and diseases that are mediated by Bruton's tyrosine kinase (Btk) activity, The disclosure also relates to the process of preparation of compounds of Formula (I).  These compounds are useful in the treatment, prevention, prophylaxis, management, or adjunct treatment of all medical conditions related to inhibition of Bruton's tyrosine kinase (Btk), such as inflammatory and/or autoimmune disorder, cell proliferation, rheumatoid arthritis, psoriasis, psoriatic arthritis, transplant rejection, graft-versus-host disease, multiple sclerosis, inflammatory bowel disease, allergic diseases, asthma, type 1 diabetes, myasthenia gravis, hematopoetic disfunction, B-cell malignancies, systemic lupus, erythematosus or other disorders.

Substituted hetero-bicyclic compounds, compositions and medicinal applications thereof

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Pune, India

Tanaji Mengawade