Chugai Seiyaku Kabushiki Kaisha

Tamotsu Yamazaki

Shun-Ichi Hata

Kazushige Sakai

Isao Matsunaga

Yasushi Murakami

Yasuhiro Ohba

Shigeru Takanashi

Takashi Mori

Minoru Shindo

Shun-ichi Hata

Sakae Takaku

Koji Mizuno

Takashi Matsuno

Shigeyuki Kataoka

Yugo Ikeda

Mitiro Takagi

Fumiaki Matsuura

Yasuyuki Shiraki

Yasuhiro Yamashita

Noboru Kubodera

Hiroyuki Nabata

Hiroyuki Nagano

Masuo Koizumi

Eiichi Hoshino

Yasuhisa Takeda

Michitaka Akima

Yukifumi Noda

Morio Kakimoto

Shin-ichi Kaiho

Yasuo Fujimura

Hiroshi Nakakimura

Sadao Tanaka

Tomohiro Neichi

Yasuyuki Katoh

Fujimura Yasuo

Kiyohiko Ito

Jinichiro Aono

Mitsura Tanemura

Yumiko Takeda

Shinichi Kaiho

Matsunaga Isao

Tanaka Sadao

A compound of the following general formula or a salt thereof ##STR1## (where R.sub.1 and R.sub.2 which may be the same or different are each an alkyl group having 1 to 3 carbon atoms; R.sub.3 is a hydrogen atom or an alkyl group having 1 to 3 carbon atoms; R.sub.4 and R.sub.5 which may be the same or different are each a hydrogen atom or an alkyl group having 1 to 8 carbon atoms; m and n which may be the same or different are each an integer of 1 to 7; provided that R.sub.4 and R.sub.5 are not a hydrogen atom at the same time), and a process of preparing the same are disclosed. The compound is useful in the treatment of arrythmias because it exhibits desirably strong effects for treating arrythmias and minimum undesirable side effects.

Novel diamine derivatives

An anti-peptic ulcer agent which contains as an active ingredient aminobenzoic acid compounds of the formula ##STR1## (wherein R.sub.1, R.sub.2, and R.sub.3 which may be the same or different represent a hydrogen atom, halogen atom, lower alkyl group or lower alkoxy group but they do not represent a hydrogen atom at the same time) or pharmaceutically acceptable salts thereof and a method of preventing or treating a human in need of said prevention or treatment an effective amount of said active ingredient are disclosed.

Anti-peptic ulcer agent

An agent for treating diseases in circulatory organs which comprises a piperazine compound of the formula ##STR1## wherein R.sub.1, R.sub.2 and A are as defined hereunder, or a salt thereof and a pharmaceutically acceptable carrier.

Compositions and methods for treating diseases in circulatory organs

Pyrazoloindazole derivatives of the formula: ##STR1## [wherein R.sub.1 is a cyano group, carboxy group, a lower alkoxycarbonyl group or a group ##STR2## (wherein R.sub.2 and R.sub.3 are each a hydrogen atom, a lower alkyl group, a phenyl group which may have a substituent or when taken together with a nitrogen atom, form a heterocyclic ring); X.sup..crclbar. is a counter ion], a process for preparing the same and a pharamaceutical composition containing the same are disclosed. The compounds of the formula above have bronchodilating action and are useful as a medicine.

Pyrazoloindazole derivatives and pharmaceutical composition containing

Novel pyrazoloindazole derivatives of the formula ##STR1## wherein R.sub.1 is a hydrogen atom, halogen atom, a hydroxyl group, a lower alkyl group, a lower alkoxyl group or benzyloxyl group; R.sub.2 is a hydrogen atom, a halogen atom, a lower alkyl group or phenyl group (provided R.sub.1 and R.sub.2 are not hydrogen at the same time); and X.sup..crclbar. is a halide ion, a hydroxide ion, a methanesulfonate ion, a p-toluene sulfonate ion, a sulfate ion, a nitrate ion, a carbonate ion, an acetate ion, a benzoate ion or a salicylate ion, a process for preparing the derivatives, and a pharmaceutical composition containing the same are disclosed. The derivatives have good bronchodilating action for human without exhibiting substantially bad effects on the functioning of heart, and therefore, they are useful as a drug.

Pyrazoloindazole derivatives and bronchodilating composition

Dibenz[b,f][1,4]oxazepine derivatives of the formula ##STR1## (wherein R.sub.1 is a hydrogen atom or a lower alkyl group; R.sub.2 is a branched lower alkyl group; R.sub.3 is a hydrogen atom, a carboxyl group, a carbamoyl group, a lower alkoxycarbonyl group, or a lower alkoxy group; R.sub.4 and R.sub.5 are each a lower alkyl group or may, when taken together with a nitrogen atom, form a heterocyclic ring; and A is a lower alkylene group) or salts thereof, a process for preparing the same and pharmaceutical compositions comprising the same are disclosed. The derivatives of the formula above are effective to prevent and treat circulatory diseases, especially angina pectoris, and therefore, useful as medicines.

Dibenz[b,f][1,4]oxazepine derivatives, process for preparing the same,

Novel compound, 1,2-bis(nicotinamido)propane and its pharmaceutically acceptable salts, a process for preparing the same and a pharmaceutical composition containing the same as an active ingredient are disclosed. The compound acts to prevent or spasmolyse cerebral vasospasms, to prevent cerebral apoplexy and to lower the lipoperoxide level in blood.

Nicotinamide derivative, process for preparing the same and

1,4,5,6-Tetrahydronicotinamide derivative represented by the formula: ##STR1## (wherein R is defined in the specification), a process of preparing the same and pharmaceutical composition containing the same are disclosed. The compound has action for suppressing aggregation of platelets, and antiinflammatory, antipyretic and analgesic actions.

Tetrahydronicotinamide derivative, pharmaceutical compositions and use

Growing community of inventors

Tokorozawa, Japan

Tamotsu Yamazaki