University of Connecticut

Tammy M Joska

Dennis L Wright

Amy C Anderson

David B Bolstad

Erin S D Bolstad

Phillip M Pelphrey

Veljko Popov

The compositions and methods described herein discloses the design, synthesis and testing of compounds that act as inhibitors of DHFR. The basic scaffold of these inhibitors includes a 2,4-diaminopyrimidine ring with a propargyl linker to another substituted aryl, bicyclo or heteroaryl ring. These DHFR inhibitors are potent and selective for many different pathogenic organisms, including the DHFR enzyme from bacteria such asand methicillin-resistant, fungi such asandand protozoa such asand. These compounds and other similar compounds are also potent against the mammalian enzyme and may be useful as anti-cancer therapeutics.

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Hartford, VT, United States of America

Tammy M Joska