Bausch-Lomb Incorporated

Tammy J Kleiber

Erning Xia

Susan E Burke

Craig M Cody

Stephen R Davio

Zora T Marlowe

Alyce K Dobie

Steven K MacLeod

Michael E Allen

Brian J Glass

Paramita Sarkar

Steven K Macleod

Brian Glass

Craig Michael Cody

Paul T Lavoie

A pharmaceutical formulation that is effective in adversely affecting the viability of microorganisms or in inhibiting their growth and that provides better safety and/or comfort to the users comprises a polysaccharide, a source of hydrogen peroxide, and an anti-oxidant. The formulation can further comprise a chelating agent and/or an ophthalmically active agent for treating or controlling a disease or disorder of the eye. The formulation may be used to treat, clean, disinfect, store, wet, or rewet contact lenses.

Pharmaceutical formulations comprising stabilized polysaccharides and source of hydrogen peroxide

A stable ophthalmic pharmaceutical composition for relief, treatment, control, alleviation, or prevention of a pathological ocular condition of the eye comprises: (a) a first polymer, a viscosity of which changes with a change in a concentration of an electrolyte, such as a salt, when added to said first polymer; (b) a second polymer that is different from the first polymer and can modify the viscosity of the first polymer; and (c) an oil. In some embodiments, the composition further comprises a non-ionic surfactant. The composition can form a stable oil-in-water emulsion on storage, but separate into an oil phase and a water phase when applied in the eye. The emulsion can comprises an ophthalmic active pharmaceutical ingredient dissolved in the oil or water phase. The emulsion can provide enhanced stability to said active pharmaceutical ingredient.

Ophthalmic pharmaceutical compositions and methods of making and using same

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Rochester, NY, United States of America

Tammy J Kleiber