Warner-lambert Company

Sankyo Company, Limited

Tammy Antonucci

Dean Lockwood

Rebecca Norris

Jerrold M Olefsky

The present invention provides methods of using thiazolidinedione in the treatment of insulin resistance.

Use of thiazolidinedione derivatives in the treatment of insulin

Novel methods of using thiazolidinone derivatives and related antihyperglycemic agents to treat populations at risk for developing noninsulin-dependent diabetes mellitus (NIDDM) and complications arising therefrom are disclosed. In one embodiment, the compounds of the invention are used to treat polycystic ovary syndrome in order to prevent or delay the onset of noninsulin-dependent diabetes mellitus. In another embodiment, the compounds of the invention are used to treat gestational diabetes in order to prevent or delay the onset of noninsulin-dependent diabetes mellitus.

Use of thiazolidinedione derivatives in the treatment of polycystic

The present invention provides methods of using thiazolidinone derivatives to treat anovulation, hyperandrogenism and hirsutism.

Use of thiazolidinedione derivatives in the treatment of anovulation,

Novel methods of using thiazolidinone derivatives and related antihyperglycemic agents to treat populations at risk for developing noninsulin-dependent diabetes mellitus (NIDDM) and complications arising therefrom are disclosed In one embodiment, the compounds of the invention are used to treat polycystic ovary syndrome in order to prevent or delay the onset of noninsulin-dependent diabetes mellitus. In another embodiment, the compounds of the invention are used to treat gestational diabetes in order to prevent or delay the onset of noninsulin-dependent diabetes mellitus.

Use of thiazolidinedione derivatives and related antihyperglycemic

Novel methods of using thiazolidinone derivatives and related antihyperglycemic agents to treat populations experiencing impaired glucose intolerance in order to prevent or delay the onset of noninsulin-dependent diabetes mellitus (NIDDM) and complications arising therefrom are disclosed.

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Thousand Oaks, CA, United States of America

Tammy Antonucci