Novartis Ag

Alcon, Inc.

Altaviz, LLC

Alcon Research, Ltd.

Old Dominion Research Foundation

Tammo Heeren

Lingfeng Yu

Steven Thomas Charles

Jack Robert Auld

John Christopher Huculak

Hugang Ren

Eric N Anderfaas

Hien Nguyen

Matthew D McCawley

Barry Lynn Wheatley

Kambiz Parto

Ron Smith

Andrew David Johnson

John C Dunne, Jr

Edouard G Schmidtlin

Steve Charles

Vadim Shofman

Michael James Papac

Karl H Schoenbach

Matthew Braden Flowers

Shu Xiao

Brian William McDonell

Roelof Trip

Argelio Michael Olivera

Mauricio Jochinsen

Stephen J Beebe

Robert Sanchez

Fred Mercado

Juergen Friedrich Kolb

Dean Lin

Richard Blomgren

Yu Lingfeng

Michael John Claus

A method and system perform an ophthalmic procedure on an eye having an optical path from the lens to the retina. An image of at least part of the eye is received in a data processing unit. The image includes the optical path. The data processing unit determines keep out zone(s) and identifies undesirable feature(s) based on the image. The keep out zone(s) include the retina. The data processing unit also selects one of the undesirable feature(s) for removal. At least part of the undesirable feature is outside of the keep out zone(s). Confirmation for removal of the undesirable feature is received in the data processing unit. In response to receiving the confirmation, a control unit controls a laser to perform laser removal the at least the portion of the undesirable feature without targeting any portion of the keep out zone(s).

Method and apparatus for performing ophthalmic procedures removing undesirable features using laser energy

Injector devices and methods for using them to deliver medicament into a patient's body, e.g., sub-retinally within an eye, are provided. The injector includes a cartridge including a piston slidably disposed within an interior for delivering medicament within the interior through an outlet, and a driver including a plunger coupled to the piston, a source of pressurized fluid, and an actuator member for opening a flow path at least partially between the source and the plunger to advance the plunger and piston to deliver medicament from the interior. One or more sensors are operatively coupled to the plunger to measure displacement of the plunger, a processor is coupled to the sensor(s) for analyzing sensor signals to measure volume of medicament delivered from the interior, and an output device, e.g., one or more LEDs or speakers, provide outputs related to the volume of medicament delivered.

Micro-volume injectors with dose guidance and methods for use

Injector devices and methods for using them to deliver medicament into a patient's body, e.g., sub-retinally within an eye, are provided. The injector includes an injector cannula having a soft injector tip. A retractable tip protector tube is slidably disposed on the flow cannula between an extended position in which the tip protector tube covers the entire injector tip, and a retracted position in which the tip protector tube is retracted proximally thereby exposing at least part of the injector tip. Accordingly, the tip protector tube protects the injector tip from being damaged while advancing the injector tip to a target injection site.

Soft tip cannula with retractable tip protector

Ophthalmic surgical devices, systems, and methods for automatically controlling the injection or extraction of viscous fluids from a patient's eye are provided. A syringe pump connected with an actuation line and a powered syringe provides pressures for viscous fluid injection or extraction in a vitreous chamber of the eye. A sensor disposed adjacent to or inside the eye determines sensor data relating to an intraocular pressure (IOP). The controller receives the sensor data and regulates the injection or extraction of the viscous fluid in response to the detected IOP, such as by controlling the syringe pump. The controller may determine whether the IOP is above an upper threshold or below a lower threshold and may control the syringe pump to regulate the injection or extraction of viscous fluid to maintain the IOP between the upper and the lower thresholds.

Automated viscous fluid control in vitreoretinal surgery

OCT-display for vitreoretinal surgery may be foot pedal controlled. Specifically, the tissue layers displayed in an en face image generated from OCT scanning may be navigated downward or upward based on user input supplied by a foot pedal device.

Foot pedal controlled OCT-display for vitreoretinal surgery

A surgical probe system comprising a surgical probe having an instrument tip, and at least one motion sensor located within the surgical probe that measures movement and orientation data. The system further includes a processor that is configured to determine movement and orientation of the instrument tip based on the movement and orientation data, and adjust at least one surgical parameter of the surgical probe based on the movement and orientation of the instrument tip to affect a predetermined surgical outcome.

Surgical probe with an integrated motion sensor

An ophthalmic surgical microscope includes a beam coupler positioned along an optical path of the surgical microscope between a first eyepiece and magnifying/focusing optics, the beam coupler operable to direct the OCT imaging beam along a first portion of the optical path of the surgical microscope between the beam coupler and a patient's eye (an OCT image being generated based on a reflected portion of the OCT imaging beam). The surgical microscope additionally includes a real-time data projection unit operable to project the OCT image generated by the OCT system and a beam splitter positioned along the optical path of the surgical microscope between a second eyepiece and the magnifying/focusing optics. The beam splitter is operable to direct the projected OCT image along a second portion of the optical path of the surgical microscope between the beam splitter and the second eyepiece such that the projected OCT image is viewable through the second eyepiece.

Surgical microscope with integrated optical coherence tomography and display systems

An ophthalmic surgical system includes an imaging unit configured to generate a fundus image of an eye and a depth imaging system configured to generate a depth-resolved image of the eye. The system further includes a tracking system communicatively coupled to the imaging unit and depth imaging system, the tracking system comprising a processor and memory configured to analyze the fundus image generated by the imaging unit to determine a location of a distal tip of a surgical instrument in the fundus image, analyze the depth-resolved image generated by the depth imaging system to determine a distance between the distal tip of the surgical instrument and a retina of the eye, generate a visual indicator to overlay a portion of the fundus image, the visual indicator indicating the determined distance between the distal tip and the retina, modify the visual indicator to track a change in the location of the distal tip within the fundus image in real-time, and modify the visual indicator to indicate a change in the distance between the distal tip of the surgical instrument and the retina in real-time.

Visualization system for ophthalmic surgery

Ophthalmic surgical devices, systems, and methods for regulating aspiration from a patient's eye are provided. A vacuum pump in fluid communication with an aspiration line provides fluid aspiration from a vitreous chamber of the eye through the aspiration line. A sensor disposed adjacent to or inside the eye determines sensor data relating to an intraocular pressure (IOP). The controller receives the sensor data and regulates the aspiration in response to changes in the IOP, such as by controlling the vacuum pump. The controller may determine whether a fluid infusion to the vitreous chamber through an infusion line is below a maximum infusion level, regulate the infusion in response to the IOP being below a threshold value and the infusion being below the maximum infusion level, and regulate the aspiration in response to the IOP being below the threshold value and the infusion being at or above the maximum infusion level.

Automated aspiration throttling in vitreoretinal surgery

Image parameters of an overlay image may be adjusted based on image parameters of an optical image displayed in a surgical microscope. The overlay image may then be displayed with the optical image to a user of the surgical microscope.

Adaptive adjustment of overlay image parameters

A method and system for extracting the zoom level of a microscope is disclosed. The method includes capturing a reference image; recording a first zoom level corresponding to a first magnification at which the reference image is captured; capturing a second image; determining a second zoom level by comparing the second image and the reference image, the second zoom level corresponding to a second magnification at which the second image is captured; and recording the second zoom level at a location accessible by a microscope application.

Extraction of microscope zoom level using object tracking

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Aliso Viejo, CA, United States of America

Tammo Heeren