Abbott Laboratories Corporation

Tammie K White

Chih-hung Lee

Sean Colm Turner

Guo Zhu Zheng

John R Koenig

Robert G Schmidt

Arthur Gomtsyan

Irene I Drizin

Erol K Bayburt

Richard J Perner

Stanley DiDomenico

Brian S Brown

Compounds of formula (I) are novel VR1 antagonists that are useful in treating pain, inflammatory thermal hyperalgesia, urinary incontinence and bladder overactivity, wherein X, X, X, X, X, R, R, R, R, R, R, Z, Zand L are as defined in the description.

Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor

The present invention relates to compounds of formula (I-VII) or a pharmaceutically acceptable salt or prodrug thereof, in which A, L, R, Rand Rare defined herein. The present invention also relates to methods of treating pain using these compounds and pharmaceutical compositions including these compounds.

Amides useful for treating pain

Compounds of formula (I) are novel VR1 antagonists that are useful in treating pain, inflammatory thermal hyperalgesia, urinary incontinence and bladder overactivity, wherein X, X, X, X, X, R, R, R, R, R, R, Z, Z, and L are defined in the description.

Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1(VR1) receptor

The present invention relates to compounds of formula (I-VII) or a pharmaceutically acceptable salt or prodrug thereof, in which A, L, R, Rand Rare defined herein. The present invention also relates to methods of trating pain using these compounds and pharmaceutical compositions including these compounds.

The isoquinoline compounds of formula (I)are VR1 antagonists that are useful in treating pain, inflammation, thermal hyperalgesia, urinary incontinence and bladder over activity. The 'R', 'Z' and &#x201c;L&#x201d; variables are defined in the disclosure and the &#x201c;X&#x201d; variables are defined as follows:

Compounds of formula (I)are novel VR1 antagonists that are useful in treating pain, inflammatory thermal hyperalgesia, urinary incontinence and bladder overactivity, wherein X, X, X, X, X, R, R, R, R, R, R, Z, Zand L are as defined in the description.

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Gurnee, IL, United States of America

Tammie K White