Eisai Company, Limited

General Director of the Agency of Industrial Science and Technology

Esai Co., Ltd.

Tamio Kawamura

Shizumasa Kijima

Yoshimasa Takahara

Hideaki Watanabe

Kenji Nakajima

Akio Sato

Yoshimasa Machida

Shigeto Negi

Isao Saito

Hiroshi Yamauchi

Noriaki Kuwana

Satoru Kato

Yasunori Ikeda

Yoshikazu Hasagawa

There are disclosed polyprenyl sulfone derivatives of the general formula: ##STR1## wherein n represents an integer of 1-4, R.sub.1 represents an aryl group d R.sub.2 represents a hydroxymethyl or carboxyl group. The polyprenyl sulfone derivatives are prepared by cultivating a microorganism of the genus Nocardia capable of oxidizing a compound of the general formula: ##STR2## wherein n and R.sub.1 have the same meanings as defined above, in a culture medium containing a compound of the above general formula (II), and then collecting the oxidation product from the culture mixture. The polyprenyl sulfone derivatives are useful as intermediates for preparing various useful polyprenyl compounds.

Polyprenyl sulfone derivatives and process for producing the same

The invention provides 3-carbamoyloxymethylcephem derivatives represented by the general formula: ##STR1## wherein R.sub.1 represents hydrogen atom or trichloroacetyl group, R.sub.2 represents hydrogen atom or methoxy group, and R.sub.3 represents hydrogen atom or hydroxyl group, or pharmaceutically acceptable salt thereof. The cephem derivatives of the invention are useful as antibacterial drugs.

3-Carbamoyloxymethylcephem derivatives, and antibacterial drugs

Polyprenyl sulfones

Novel process for biochemical optical resolution of 2DL-racemic compound of .alpha.-tocopherol ester or substances which contain the same, using culture broth, whole cell, or culture filtrate, which are obtained by cultivating microorganisms which possess an ability for hydrolysis of said ester. Beneficial advantage of the process resides in its low cost, simplicity and high resolution ratio.

Process for biochemical optical resolution of alpha-tocopheral

Growing community of inventors

Kakamigahara, Japan

Tamio Kawamura