Cytosorbents Corporation

University of Pennsylvania

General Electric Company

Tamaz Guliashvili

Thomas D Golobish

Vincent J Capponi

Maryann Gruda

Phillip Chan

Wei-Tai Young

Andrew Scheirer

Pamela O'Sullivan

Vi Dan

Virgil Percec

Anatoliy V Popov

Stephen Robert Vasconcellos

Josh Vichare

Timothy Kovacs

David James

Karl-Gustav Ruggeberg

Sarah Patterson

The invention concerns biocompatible polymer systems comprising at least one polymer with a plurality of pores, said polymer comprising a sulfonic acid salt functionality designed to adsorb a broad range of protein based toxins from less than 0.5 kDa to 1,000 kDa and positively charged ions including but not limited to potassium.

Multi-functional hemocompatible porous bead sorbent for removing protein based toxins and potassium from biological fluids

The invention concerns polymeric media based on modified natural polysaccharides for removing one or both of Anti-A Antibodies and Anti-B Antibodies from human blood or plasma, the media comprising one or both of (i) a polymeric solid support with a blood group A Antigen ligand attached to the solid support at a ligand loading between 1-5 mg/mL of solid support, and wherein the media is stable under physiological pH conditions, and (ii) a polymeric solid support with a blood group B Antigen ligand attached to the solid support at a ligand loading between 1-5 mg/mL of solid support, and wherein the media is stable under physiological pH conditions.

Crosslinked polysaccharide based absorbents for removal of anti-A and/or anti-B antibodies from human plasma and whole blood

The invention concerns biocompatible polymer systems comprising at least one polymer with a plurality of pores, said polymer comprising either polyol or zwitterionic groups designed to adsorb endotoxins and other inflammatory mediator molecules. The inventions are in the field of porous polymeric sorbents, also in the field of broadly reducing endotoxins in blood and blood products that can cause endotoxemia, additionally, in the field of broadly removing endotoxins by perfusion or hemoperfusion.

Use of a hemocompatible porous polymer bead sorbent for removal of endotoxemia-inducing molecules

Multi-functional hemocompatible porous polymer bead sorbent for removing protein based toxins and potassium from biological fluids

This invention discloses methods for reducing physiologic molecules in abnormal levels and/or exogenous toxins in blood from blood by way of an extracorporeal circuit comprising a hollow-fiber filter module and polymer sorbent in combination.

Methods for removal of toxins from blood using an extracorporeal circuit comprised of a hollow-fiber filter module and polymer sorbent in combination

The invention involves functionalizing polymeric beads, such as DVB beads, to add an epoxide or aldehyde group. The resulting beads are useful in various applications.

Process for functionalizing a biocompatible polymeric bead, the functionalized beads, and the beads produced thereby

Methods are provided for making halide-free quaternary ammonium salt monomers. Polymers prepared from the monomers and methods of using the polymers to clarify raw, untreated water or wastewater are also disclosed.

Methods of preparing novel halide anion free quaternary ammonium salt monomers, polymerization methods therefor, and methods of use of the resulting polymers

Acrylic polymers are made by the living radical polymerization of acrylic monomers utilizing organo halide initiators with either metal-free or metal catalysts. Moreover, block copolymers of vinyl halide monomers and acrylic monomers are described by generally polymerizing either the vinyl halide monomers or acrylic monomers utilizing an organo halide initiator in the presence of either a metal catalyst or a metal-free catalyst and subsequently polymerizing thereon the remaining type of monomer.

Living radical polymerization of acrylic monomers and the formation of block copolymers therefrom

Living radical polymerization of halogen-containing and acrylic monomers and the formation of block copolymers therefrom

Growing community of inventors

Philadelphia, PA, United States of America

Tamaz Guliashvili