Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt.

Tamas U Kallay

Laszlo Ledniczky

Gabor T Szabo

Dezso Korbonits

Pal Kiss

Gergely Heja

Endre Palosi

Csaba Gonczi

Tibor Montay

Zsuzsanna Nad

Lajos T Nagy

Eva Somfai

Ida Szvoboda Nee Kanzel

Maria Szomor Nee Wundele

Judit Cser Nee Kun

Gyorgy Lanyi

Maria Sziladi

Lajos Imrei

Gabor Kovacs

Kalman Harsanyi

Gyorgy Lugosi

Vilmos Simonidesz

Geza Toth

Laszlo Simandi

Judit Kun

Gabor Besenyei

Peter Gyory

Istvan Jelinek

Erzsebet Szalay

Robert Gepesz

Valeria Denes Nee Lustig

Maria Szomor

Laszlo Rvai

Gyorgy Hoffmann

Marta Lugosi

Ilona Santa Nee Singola

Ida Szvoboda Nee Kauzel

Csaba Gunczi

Ida Szvoboda

Judit Cser

Antal Friesz

The present invention relates to a process for the preparation of L-isomer of propargyl-ammonium-chloride derivatives of the formula (I) ##STR1## by decomposing D-tartarte of L-isomer of the amine of the general ##STR2## wherein y is hydrogen or fluoro and by reacting the obtained L-issomer amine of the formula (II) in the presence of a base with a halide of the formula (V), X--CH.sub.2 --C.ident.CCH wherein X is halogen and by reacting the so obtained L-isomer of the Formula (III) ##STR3## with hydrogen-chloride in an organic solvent, wherein x is a halogen atom,

Process for the preparation of propargyl ammonium-chloride

Process for the preparation of substituted isoflavone derivative

Process for the preparation of ketone compounds

Process for the preparation of pharmaceutical compositions

The invention relates to a process for the preparation of a new crystalline monohydrate of 1-(3', 4'-diethoxy-benzyl-6, 7-diethoxy-3,4-dihydro-isoquinolinium-theophylline-7-acetate and if desired of pure 1-(3', 4'-diethoxy-benzyl)-6,7-diethoxy-3, 4-dihydro-isoquinolinium-theophylline-7-acetate free of contaminating oxidation products which comprises reacting 1-(3',4'-diethoxy-benzyl)-6,7-diethoxy-3,4-dihydro-isoquinolinium with theophylline-7-acetate acid in the presence of water and one or more organic solvent(s) and if desired dehydrating the 1-(3',4'-diethoxy-benzyl) 6,7-diethoxy-3,4-dihydro-isoquinolinium-theophyl line-7-acetate-monohydrate thus obtained.

Process for the preparation of depogen

The invention relates to a process for the preparation of compounds of formula (I) ##STR1## wherein R.sup.1 stands for hydrogen or the group COR.sup.2, wherein

Process for the preparation of diphenyl ether derivatives

2-(3-phenoxy-phenyl)-propionic acid or its pharmaceutical treatments, are prepared by hydrolyzing and partially decarboxylating ##STR1## wherein R=C.sub.1 -C.sub.6 alkyl or amino, the latter compounds being themselves new and, where R=C.sub.1 -C.sub.6 alkyl, have antiinflammatory pharmaceutical properties.

2-Cyano-2-(3-phenoxy-phenyl)-propionic acid amide and preparation thereof

2-(3-Phenoxy-phenyl)-propionic acid or its pharmaceutical treatments, are prepared by hydrolyzing and partially decarboxylating ##STR1## wherein R=C.sub.1 -C.sub.6 alkyl or amino, the latter compounds being themselves new and, where R=C.sub.1 -C.sub.6 alkyl, have antiinflammatory pharmaceutical properties.

Process for the preparation of 2-(3-phenoxy-phenyl)-propionic acid

3-Phenoxybenzene derivatives are prepared by a method which comprises the steps of(a) chlorinating benzaldehyde with chlorine gas in the presence of a hydrocarbon and a Lewis acid catalyst to obtain 3-chlorobenzaldehyde; (b) reacting the 3-chlorobenzaldehyde with ethylene glycol to obtain 2-(3-chlorophenyl)-1,3-dioxolane; (c) etherifying said dioxolane with an alkali phenolate to yield the intermediate 2-(3-phenoxyphenyl)-1,3-dioxolane and converting this intermediate to the corresponding aldehyde, cyanohydrin, sulfonic acid salt or oxime derivative.

Process for the preparation of 3-phenoxybenzenes

A process for the preparation of a substituted-phenyl-N-alkyl-carbamate of the formula ##STR1## wherein R.sup.1 and R.sup.2 form part of a carbamoyloxy group and are identical or different and each is hydrogen or lower alkyl,

Process for the preparation of substituted-phenyl-N-alkyl-carbamates

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Budapest, Hungary

Tamas U Kallay