Micromass UK Limited

Thalesnano Zrt.

Tamas Karancsi

Steven Derek Pringle

Daniel Szalay

Lajos Godorhazy

Zoltan Takats

Daniel Simon

Julia Balog

Emrys Jones

Keith George Richardson

Michael Raymond Morris

James Ian Langridge

Frances Bolt

Phillip Robert Bennett

David Alan MacIntyre

Pamela Pruski

Ian David Trivett

Stephen O'Brien

Alvin Chua

Anthony Hesse

Matt Henderson

Ferenc Darvas

Jeremy Kirk Nicholson

Ferenc Boncz

László Ürge

James Kinross

Zoltan Takáts

A method of analysis using mass and/or ion mobility spectrometry or ion mobility spectrometry is disclosed comprising: using a first device to generate aerosol, smoke or vapour from one or more regions of a first target of biological material; and mass and/or ion mobility analysing and/or ion mobility analysing said aerosol, smoke, or vapour, or ions derived therefrom so as to obtain first spectrometric data. The method may use an ambient ionisation method.

Tissue analysis by mass spectrometry or ion mobility spectrometry

A method is disclosed comprising providing a biological sample on a swab, directing a spray of charged droplets onto a surface of the swab in order to generate a plurality of analyte ions, and analysing the analyte ions.

Rapid evaporative ionisation mass spectrometry ('REIMS') and desorption electrospray ionisation mass spectrometry ('DESI-MS') analysis of swabs and biopsy samples

An apparatus for performing ambient ionization mass and/or ion mobility spectrometry is disclosed. The apparatus comprises a substantially cylindrical, tubular, rod-shaped, coil-shaped, helical or spiral-shaped collision assembly; and a first device arranged and adapted to direct analyte, smoke, fumes, liquid, gas, surgical smoke, aerosol or vapor onto said collision assembly.

Collision surface for improved ionisation

A method of analysis using mass spectrometry and/or ion mobility spectrometry is disclosed. The method comprises: using a first device to generate smoke, aerosol or vapour from a target comprising or consisting of a microbial population; mass analysing and/or ion mobility analysing said smoke, aerosol or vapour, or ions derived therefrom, in order to obtain spectrometric data; and analysing said spectrometric data in order to analyse said microbial population.

Spectrometric analysis of microbes

A method of mass spectrometry or ion mobility spectrometry is disclosed comprising: providing an analyte; supplying a matrix compound to said analyte such that said analyte dissolves in said matrix; forming first droplets of the dissolved analyte; and colliding said first droplets with a collision surface. The use of matrix improves the analyte ion signal.

Ionisation of gaseous samples

An apparatus is disclosed including a tool comprising a first device for generating aerosol from a target, the first device being deployed through an opening in a tubing of the tool, wherein the tubing is provided with aspiration ports or fenestrations such that the generated aerosol is aspirated into the tubing via the aspiration ports or fenestrations. The aspirated aerosol is then transferred to a mass spectrometer for subsequent mass analysis.

In vivo endoscopic tissue identification tool

A method of analysis is disclosed comprising providing a sample on an insulating substrate such as a petri dishand contacting e.g. the rear surface of the insulating substrate with a first electrode. The method further comprises contacting the sample with a second electrodeand applying an AC or RF voltage to the first and second electrodesin order to generate an aerosol from the sample.

Capacitively coupled REIMS technique and optically transparent counter electrode

An apparatus for performing ambient ionisation mass and/or ion mobility spectrometry is disclosed. The apparatus comprises a substantially cylindrical, tubular, rod-shaped, coil-shaped, helical or spiral-shaped collision assembly; and a first device arranged and adapted to direct analyte, smoke, fumes, liquid, gas, surgical smoke, aerosol or vapour onto said collision assembly.

A method of analysis is disclosed comprising providing a sample on an insulating substrate such as a petri dish () and contacting e.g. the rear surface of the insulating substrate with a first electrode (). The method further comprises contacting the sample with a second electrode () and applying an AC or RF voltage to the first and second electrodes () in order to generate an aerosol from the sample.

An apparatus for mass spectrometry and/or ion mobility spectrometry is disclosed comprising a first device arranged and adapted to generate aerosol, smoke or vapour from a target and one or more second devices arranged and adapted to aspirate aerosol, smoke, vapour and/or liquid to or towards an analyser. A liquid trap or separator is provided to capture and/or discard liquid aspirated by the one or more second devices.

Liquid trap or separator for electrosurgical applications

An apparatus for mass spectrometry and/or ion mobility spectrometry is disclosed comprising a first device arranged and adapted to generate aerosol, smoke or vapor from a target and one or more second devices arranged and adapted to aspirate aerosol, smoke, vapor and/or liquid to or towards an analyzer. A liquid trap or separator is provided to capture and/or discard liquid aspirated by the one or more second devices.

A method is disclosed comprising providing a biological sample on a swab, directing a spray of charged droplets onto a surface of the swab in order to generate a plurality of analyte ions, and analyzing the analyte ions.

A process for hydrogenating a sample in a pressure range below supercritical pressure values includes supplying at least a solvent of the sample to be hydrogenated by a feed pump with a constant volume rate into a flow path to create a base solution; adding the sample being dissolved into the flow path; feeding hydrogen into the flow path through a valve configured to transmit hydrogen only into a single direction; leading the dissolved sample in the presence of a catalyst through a hydrogenation reactor, where the reactor is inserted into a section of the flow path located after the hydrogen feeding position; maintaining the pressure of the reaction in a given pressure range by element of a pressure-adjusting unit, and collecting a hydrogenate formed within the hydrogenation reactor in a product receptacle connected to the end of the flow path.

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Budapest, Hungary

Tamas Karancsi