Yeda Research and Develpment & Co. Ltd

Tamar Danon

Irit Sagi

Abraham Shanzer

Rina Arad-Yellin

Netta Sela

Raghavendra Kikkeri

Raanan Margalit

Netta Sela-Paswell

An antibody comprising an antigen recognition region which comprises CDR amino acid sequences set forth in SEQ ID NO: 7, 8, 9, 10, 11 and 12.

Antibodies and pharmaceutical compositions containing same useful for inhibiting activity of metalloproteins

An antibody is disclosed which comprises an antigen recognition region which comprises six CDR amino acid sequences selected from the group consisting of SEQ ID NOs: 4-15. Uses thereof are also disclosed.

Antibodies that inhibit metalloproteins

A method of producing a metalloprotein inhibitor, the method comprising generating antibodies directed at a composition including a metal ion-bound chelator, wherein the composition is selected having structural and electronic properties similar to a functional domain of the metalloprotein, thereby producing the metalloprotein inhibitor.

The present application relates to antibodies which recognize [2(2-aminoethylcarbomoyl)-ethoxymethyl]-tris-[2-N-(3-imidazol-1-yl-propyl))-ethoxymethyl]methane, a hapten molecule which closely mimics the local structure and conformation of the reactive zinc site in matrix metalloproteinases. An antibody is disclosed which comprises an antigen recognition region which comprises six CDR amino acid sequences selected from the group consisting of SEQ ID NOs: 4-15. Uses thereof are also disclosed.

The present invention relates to a compound having the general Formula (I): 

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Rehovot, Israel

Tamar Danon