Biolife, L.l.c.

Biosearch, LLC

Talmadge Kelly Keene

John Hen

Mark Travi

John Alfred Thompson

Charles E Entenmann

James A Patterson

Louis M Guzzi

Roger Thomas

James V Benson

David Cottrell

Michael H Tollon

Kurt Vadelund

John Tifton Fordham

Rebecca Van Orden

James W Reding

A composition and method useful in promoting healing of a bleeding wound site. The composition preferably includes a substantially anhydrous acid form of a cation exchange resin, which when applied over blood, provides an antimicrobial against planktonic microorganisms and biofilms in the wound. The resin is also capable, when applied in sufficient quantities, of providing a continuing and persistent antimicrobial against planktonic microorganisms and biofilms through dehydration and ion exchange with cations present in the blood and other body fluids. When the resin has a concentration of at least 26 mg/ml, it provides a &#x3e;3 log reduction in biological activity of MRSA, MRSE and

Composition and method for arresting blood flow and for forming a persistent microbial barrier

A wound sealing powder, method of making a wound sealing powder, and method of using a wound sealing powder to reduce blood flow from a wound are provided. Specifically, the wound sealing powder utilizes a particulate powder material of an effective amount of an insoluble cation exchange material wherein the majority of the particles in the powder have particle sizes of less than approximately 48 microns.

Wound sealing powder

This invention is directed to devices and methods for improving wound closures produced during endoscopic surgery. These methods are directed to delivering and applying a quantity of hemostatic agents in either powder, solid, liquid, or gel form onto an open wound produced e.g., by polyp removal, followed by the application of pressure. The method is implemented preferably using existing endoscopic equipment; however, modifications to existing endoscopic insertion tubes, application and tamping devices and endoscopic clips deployed from the distal end of the insertion tube during endoscopic surgery are also within the scope of this invention.

Adaptive devices and methods for endoscopic wound closures

A hemostatic tablet preferably including potassium ferrate and a cation ion exchange resin pressure formed into a tablet for delivery to a bleeding wound. The tablet improves the rate of adhesion to a bleeding wound surface, and allows a significantly greater and more uniform pressure to be exerted by manual compression of the tablet on the wound site, as compared to that of a thin layer of scattered hemostatic powder. After the seal is formed from the interaction of blood or exudates with the immediate contacting surface of the tablet, the bulk of the unused tablet easily delaminates from the seal making clean up facile. If the unused portion of the tablet is not removed from the wound site, a reservoir of hemostatic dressing stops further bleeding and to provide antimicrobial protection and healing. The tablet may be applied to any surface orientation and take any shape and thickness possible.

Hemostatic device and method

An electrical cell and method for generating electrical power are disclosed for producing electrical energy from a gas such as hydrogen and isotopes thereof. The electrical cell comprises an ionizing material located within an interior volume of a housing for absorbing the gas and separating ions and electrons. An electron collector receives electrons generated by the ionizing material. An insulator material within the housing inhibits electrons from entering into an ion collector while allowing the gas and the ions to pass to the ion collector for generating electrical voltage between the electron collector and the ion collector.

Electric energy cell

A method of arresting blood flow from a bleeding wound including the steps of (1) providing a solid hemostatic tablet preferably including potassium ferrate and a cation ion exchange resin pressure formed into a tablet for delivery onto a bleeding wound, the tablet defining a proximal portion and a distal portion, (2) applying the proximal portion against the bleeding wound to improve the rate of adhesion to a bleeding wound surface, and then (3) applying pressure against the tablet over the wound site. After the seal is formed from the interaction of blood or exudates with the proximal portion of the tablet, the distal portion of the tablet delaminates from the proximal portion to form a reservoir to stop further bleeding and to provide antimicrobial protection and healing. The tablet may be applied to any surface orientation and take any shape and thickness possible.

A composition and method of arresting the flow of blood from a bleeding wound. The composition preferably includes an anhydrous salt ferrate compound preferably combined with an effective amount of an insoluble cation exchange material and an effective amount of anhydrous Magnetite mixed uniformly together. Povidone iodine may be added for enhanced antimicrobial properties. In the method, a quantity of the composition is magnetically attached to a surface of a magnet, after which the powderous mixture is applied to the wound by pressing the surface covered with the powderous compound against the wound for a time sufficient to clot the blood to arrest substantial further blood flow from the wound.

Hemostasis composition with magnetite

A composition and method useful in promoting hemostasis, absorbing ooze, and being antimicrobial with respect to an open wound. The composition broadly includes an antimicrobial agent, preferably povidone iodine, preferably a ferrate compound, and a cation ion exchange resin. This composition will destroy a biofilm which has formed over the open wound in providing a soluble iron compound, a cation chelation compound, and an active antimicrobial compound effective against planktonic microorganisms and biofilms. The antimicrobial agent is locked or sealed within the scab formed over the wound to maintain long-term positioning and anti-dilution of the antimicrobial over the wound.

Ferrate and povidone iodine (PI) composition

The subject invention pertains to materials and methods for stopping or decreasing the blood flow from an open wound or medical or surgical procedure. Compositions of the invention comprise a salt form of a cross-linked polyacrylic acid. In one embodiment, the composition comprises a sodium salt of a polyacrylic acid. Compositions of the invention can also optionally comprise one or more different salt ferrates, and/or a cationic exchanger resins, and/or a silver compound. In an exemplified embodiment, a composition of the invention comprises sodium polyacrylate provided in a dry powdered form. Polyacrylate compositions of the invention can be applied directly to a wound or treatment site, or they can be incorporated into a wound dressing, such as a bandage. The clot or scab formed at a wound or treatment site treated with the present invention is extremely elastic and exhibits considerable tensile strength when stretched to the breaking point. The subject invention also concerns wound and surgical site dressings and coverings, and methods of using a composition of the invention to stop blood flow from an open wound or treatment site.

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Ruskin, FL, United States of America

Talmadge Kelly Keene