Sunovion Pharmaceuticals Inc.

Pgi Drug Discovery LLC

Psychogenics Inc.

Sumitomo Pharma America, Inc.

Campbell, John Emmerson

Shao, Liming

Campbell, Una

Hanania, Taleen G.

John Emmerson Campbell

Una Campbell

Liming Shao

Taleen G. Hanania

Taleen G Hanania

Philip Glyn Jones

Linghong Xie

Vadim Alexandrov

Michael Charles Hewitt

Noel Aaron Powell

Kerry Leigh Spear

Michele L R Heffernan

Sharon Rae Engel

Milan Chytil

Emer Leahy

Carrie A Bowen

Michele LR Heffernan

John Emerson Campbell

Disclosed are compounds of formula (I): and pharmaceutical compositions containing such compounds. Methods of treating neurological or psychiatric disease and disorders in a subject in need are also disclosed.

Compounds and compositions and uses thereof

Provided herein are thiophene compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or management of various neurological disorders, including but not limited to, psychosis and schizophrenia.

Heteroaryl compounds and methods of use thereof

Disclosed are compounds of Formula (I): and pharmaceutically acceptable salts thereof, wherein A, R, R, R, R, R, R, w and n1 are defined and described herein; compositions thereof; and methods of use thereof. These compounds are useful for treating a variety of neurological and psychiatric disorders, such as those described herein.

1-heterocyclyl isochromanyl compounds and analogs for treating CNS disorders

Compounds of formula I: are disclosed, as are pharmaceutical compositions containing such compounds. Methods of treating neurological or psychiatric diseases and disorders in a subject in need thereof are also disclosed.

Provided herein are multicyclic compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or management of various neurological disorders, including but not limited to, psychosis and schizophrenia.

Multicyclic compounds and methods of use thereof

Provided herein are multicyclic compounds of formula (IVa), shown below, wherein R, R, R, R, R, R, R, m, and n are defined herein elsewhere, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or management of various neurological disorders, including but not limited to, psychosis and schizophrenia. 

Disclosed are compounds of Formula (I): and pharmaceutically acceptable salts thereof, wherein Ring B, A, A, R, w and n1 are defined and described herein; compositions thereof; and methods of use thereof. These compounds are useful for treating a variety of neurological and psychiatric disorders, such as those described herein.

Fused dihydro-4H-pyrazolo[5,1-C][1,4]oxazinyl compounds and analogs for treating CNS disorders

Provided herein are multicyclic compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. For example, disclosed herein are compounds having formula (IIa) shown below, or a pharmaceutically acceptable salt or stereoisomer thereof, wherein the variables are defined herein. The compounds provided herein are useful for the treatment, prevention, and/or management of various neurological disorders, including but not limited to, psychosis and schizophrenia. 

Growing community of inventors

Valhalla, NY, United States of America

Taleen G Hanania