University of Sharjah

Taleb H Altel

Raafat A El-Awady

Srinivasulu Vunnam

Farah Ibrahim Al-Marzooq

Hany A Omar

Vunnam Srinivasulu

Amjad Ali

Amin Majdalawieh

Mawieh Hamad

Cijo George Vazhappilly

Mohamad Hamad

Saleh Ibrahim

Shifaa Abdin

Imad Abu Yousef

Paul Schilf

The present invention relates to novel antitumor agents and pharmaceutically acceptable salts thereof, processes and intermediates for the manufacture of these novel constrained cyclic frameworks of general formula I and II, and medicaments containing such compounds.

Discovery of novel first in class nature-inspired compounds targeting the mitochondrial function and pharmaceutical composition thereof

A compound represented by following formula I: according to the present disclosure. The disclosed compound is useful in the treatment of many disease states related to cell proliferation. In particular, new pyran derivatives are provided along with processes for preparations and methods for pharmaceutical applications, for example, as anticancer agents. The compound was found to have antiproliferative effects against multiple cancer cell lines and showed low toxicity to normal fibroblasts. The disclosed compound also exhibited anticancer properties by inducing caspase-mediated cell death mechanisms and arresting cancer cell progression. Further, the compound represented by Formula I targets multiple key proteins/enzymes, including thioredoxin reductase, glutathione reductase, transferrin receptors, inisitol-3-phosphate synthase, cystolic aminopeptidase, and transketolase, which are over-expressed in tumor cells.

Heterocyclic systems and pharmaceutical compositions thereof

There is provided novel anticancer and antibacterial compounds, pharmaceutically acceptable salts thereof, and processes for their preparation. The compounds have anticancer activity, which results in the reduction of tumour cell proliferation, enhances cancers cells apoptosis and regulation of iron signalling. The compounds are also particularly active against various Gram-negative and Gram-positive multidrug-resistant bacteria, such as extended-spectrum beta-lactamase (ESBL) producing and colistin-resistant, carbapenem-resistant, carbapenem-resistant, and methicillin-resistant(MRSA) including those with reduced susceptibility to many control antibiotics.

Nature-inspired anticancer and antibacterial motifs and pharmaceutical composition thereof

Novel heterocyclic fused systems are disclosed herein which possess numerous biological activities, including but not limited to antibacterial activity, and usefulness to the treatment of many disease states, such as pathogenic infections. In particular, new imidazoles are disclosed along with related processes of preparation and methods of use as antibacterial agents. The disclosed compounds were found to be active against several Gram-positive bacteria, includingand, and were also found to be active against several species of multi-drug resistant, such as, and

Heterocyclic systems and pharmaceutical applications thereof

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Sharjah, United Arab Emirates

Taleb H Altel