Kimberly-Clark Worldwide, Inc.

Baker Hughes Corporation

Avent, Inc.

Talbot Presley

Richard Joseph Hantke

Erica M Phillips

Daniel Duncan Baird

Thomas Edward Plowman

Mike Rainone

Douglas James Murray

Michael D Rainone

Priyesh Ranjan

Shawn Ray Feaster

Gary B Lake

Samuel Albert Sackett

Michael J May

Richard Hantke

A linear motor activator for a downhole safety valve including a permanent magnet carrier; a plurality of permanent magnets mounted to the permanent magnet carrier; a coil carrier disposed in magnetic field proximity to the permanent magnet carrier; and a plurality of coils mounted to the coil carrier, one of the permanent magnet carrier and the coil carrier being movable relative to the other of the permanent magnet carrier and coil carrier, and being connected to a component of a downhole safety valve and method.

Permanent magnet linear motor actuated safety valve and method

Disclosed herein are methods and devices for detection of bacterial HAI. Disclosed methods may be utilized for continuous in vivo monitoring of a potential bacterial infection site and may be utilized to alert patients and/or health care providers to the presence of pathogenic bacteria at an early stage of infection. Disclosed methods include utilization of recombinant bacteriophage to deliver to pathogenic bacteria a translatable genetic sequence encoding an optically detectable marker or an enzyme capable of producing an optically detectable marker. Upon detection of the optical signal produced by the marker, medical personnel may be alerted to the presence of pathogenic bacteria at the site of inquiry. Any bacterial causative agent of HAI may be detected according to disclosed methods.

Recombinant bacteriophage for detection of nosocomial infection

Disclosed are methods and devices for continuous in vivo monitoring of a potential bacterial infection site. Disclosed devices may be utilized to alert patients and/or health care providers to the presence of pathogenic bacteria at an early stage of a hospital acquired infection, thereby providing for earlier intervention. Disclosed methods utilize optical fibers to deliver an excitation signal to an area in which pathogenic bacteria may exist. In the presence of the excitation signal, bacterial pathogens may autofluoresce with a unique spectral signature. Upon generation of a fluorescent emission, an optically detectable emission signal may be transmitted to a detection/analysis device. Analysis of the characteristics of the emission signal produced in response to the excitation signal may be used to determine the presence or concentration of pathogens at the site of inquiry, following which real time information may be transmitted to medical personnel via a wireless transmission system.

Fiber optic based detection of autofluorescent bacterial pathogens

Disclosed herein are methods and devices for detection of hospital acquired infections. Disclosed methods may be utilized for continuous in vivo monitoring of a potential infection site or for periodic in vitro monitoring of tissue or fluid from a patient and may be utilized to alert patients and/or health care providers to the presence of a pathogen at an early stage of infection. Disclosed methods utilize fluorophore pairs that optically interact with one another according to Forster resonance energy transfer (FRET) or bioluminescence resonance energy transfer (BRET) mechanism. One member of the pair or a cofactor that interacts with an enzyme to form a member of the pair may be tethered to a device by a substrate that is specific for an enzyme expressed by a targeted pathogen. Upon interaction of the enzyme with the substrate, an optically detectable signal may be altered or initiated, detection of which may then provide information as to the existence of the pathogen at the site.

Resonance energy transfer based detection of nosocomial infection

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Palestine, TX, United States of America

Talbot Presley