Logicink Corporation

National Institutes of Health, a Component of the US Dept. of Health & Human Services

Columbia University

Tal Danino

Marcelo Henrique Coelho

Carlos Olguin

Ian Fritz

Skylar Tibbits

Skylar J E Tibbits

Carlos Edel Olguin Alvarez

Nicholas Arpaia

Sreyan Chowdhury

Skylar Jackson Eagle Tibbits

Candice Gurbatri

Disclosed herein are programmable bacteria for tumor-targeted immunotherapeutic delivery. In certain embodiments, the programmable bacteria comprise at least one synchronized lysis circuit contained in a single operon which are capable of being further engineered to cyclically produce anti-cancer therapeutic agents including but not limited to nanobodies against immune checkpoint inhibitors and over-expressed markers in cancers, toxins, tumor antigens, cytokines, and chemokines. In some embodiments, the programmable bacteria comprise at least one synchronized lysis circuit contained in a single operon and at least one plasmid producing a therapeutic agent, i.e., at least one plasmid comprising a nucleic acid sequence which encodes a therapeutic agent. The disclosure also provides methods of curing and treating cancer using the programmable bacteria.

Programmable bacteria for the treatment of cancer

A wearable device may be provided for detecting cumulative alcohol consumption. Such a wearable device may include an adhesive layer that adheres to skin and that allows sweat from the skin to pass through and a customizable ink layer that reacts irreversibly to change color along a gradient as ethanol is detected in the sweat. The customizable ink continues to increase color intensity along the gradient as ethanol continues to be detected in the sweat over time.

Cumulative biosensor system to detect alcohol

A dynamic sensor interface is provided. Such a dynamic sensor interface may include a reaction portion that includes a biological-based or chemical-based ink. Such ink reacts in response to a molecule of interest. The dynamic sensor interface may further include an electrode that detects the reaction by the ink in response to the molecule of interest, as well as a signal interface that emits a signal based on the electrode detecting the reaction. Such a dynamic sensor interface allows for information to be detected and communicated through and between both bio-chemical and electronic systems.

Communication using programmable materials

This disclosure relates to a tattoo decal containing bacteria that can be applied to skin and function as both a monitoring sensor and a visual indicator. In particular, a temporary tattoo containing a bacteria composite that may be selected or 'programmed' to sense, detect, or otherwise react to a variety of stimuli for use in a variety of applications and industries is disclosed.

Programmable bacterial tattoo

Growing community of inventors

New York, NY, United States of America

Tal Danino