Toko Yakuhin Kogyo Kabushiki Kaisha

Toko Yakuhin Industry Co., Ltd.

Fujisawa Pharmaceutical Company, Ltd.

Toko Yakuhin Kogyo Co., Ltd.

Takuzo Kamishita

Takashi Miyazaki

Kazuhiko Kamishita

Yoshihide Okuno

Suminori Umio

Yasuhiro Mine

Toshiaki Kamimura

Toshiaki Takagi

Shigeyoshi Hiraki

Antifungal composition for external use being retentive in stratum

A quick-drying, gel-type disinfectant composition useful for disinfecting the hands and fingers of workers such as doctors and nurses and patients in hospitals, which can readily be used without overflowing or falling from the hands and fingers and can be well spreaded onto the hands and fingers by rubbing with neither occurrence of twisted scale-like residue nor unpleasant stickiness before or after drying, which comprises a solution of a disinfectious medicament in an alcohol and a thickening agent consisting of a combination of a carboxyvinyl polymer and a water-soluble, high molecular cellulose compound.

Quick-drying gel-type disinfectant for hands and fingers

A spray gel base having an excellent spread-stick property, which is prepared by thickening a 0.2-1.5 % by weight aqueous solution of carboxyvinyl polymer with a water-soluble basic substance, followed by adjusting the viscosity thereof with a viscosity adjustor within the range of 500-5,000 centipoise so that the particle size distribution of spray after spraying is over 80% in the area of 20-100 .mu.m and a spray gel preparation having an excellent spread-stick property, which is prepared by mixing an active medicament with said spray gel base.

Spray gel base and spray gel preparation using thereof

A spray base gel having an excellent spread-stick property, which is prepared by thickening a 0.2-1.5% by weight aqueous solution of carboxyvinyl polymer with a water-soluble basic substance, followed by adjusting the viscosity thereof with a viscosity adjustor within the range of 500-5,000 centipoise so that the particle size distribution of spray after spraying is over 80% in the area of 20-100 .mu.m and a spray gel preparation having an excellent spread-stick property, which is prepared by mixing an active medicament with said spray gel base.

A disposable nozzle adapter for intranasal administration of a viscous medical solution in combination with a spray container, which comprises a cylindrical body, a rod arranged in the body, and a nozzle tip. The body has a cylindrical chamber and a central bore communicated with the chamber through a channel for attachment of the spray container. The rod is provided on its one end at the least with a small-sized portion and middle-sized portion. The nozzle tip has a top wall and a cylindrical portion extending therefrom, the top wall being provided with a central spray opening including a tapered recess, and swirl grooves extending outwardly from the tapered recess to the inner surface of the cylindrical portion. The swirl grooves have a cross-sectional area increasing outwardly and its cross-sectional area is 0.03 to 0.08 mm.sup.2 at the minimum. The nozzle tip is fitted in the opening of the chamber of the body and engaged with the middle-sized portion of the rod to form an annular channel surrounding the small-sized portion of the rod and being communicated with the grooves.

Disposable nozzle adapter for intranasal spray containers

A gel ointment base having stable viscosity and resistant to a light which comprises an aqueous carboxyvinyl polymer solution and an amino acid in an amount effective for increasing the viscosity of the aqueous carboxyvinyl polymer solution, and a gel ointment comprises an active medical substance and the gel ointment base as set forth above, which has stable viscosity and resistant to a light at a pH range which does not give any irritation to viscous membranes and skins.

Method for inhibiting the decrease in viscosity of gel ointment base and

Anti-inflammatory, stable and painless topical gel preparations comprising diclofenac sodium as the active ingredient; water, ethanol and a glycol as the solvent medium; a carboxyvinyl polymer obtained by the polymerization of acrylic acid as a gelling agent; and a weakly basic aliphatic amine as a neutralizing agent for the carboxyvinyl polymer.

Gel preparations for topical application of diclofenac sodium

This invention relates to an antifungal composition containing pyrrolnitrin and an antimycotic imidazole compound as active ingredients.

Antifungal composition employing pyrrolnitrin in combination with an

A pharmaceutical preparation for external use which comprises a solution of a non-steroid antipholgistic analgesic agent which is dissolved in at least one adjuvant selected from the group consisting of peppermint oil, methyl salicylate, ethyl salicylate and monoglycol salicylate in an amount at least sufficient to dissolve said antipholgistic analgesic agent, and bases for external use.

Pharmaceutical preparations

A gel preparation for external application by being prepared from diclofenac sodium as the active ingredient, water, lower alkanols and glycols as medium, a carboxyvinyl polymer as gelating agent, a weak basic substances and optionally adding peppermint oil, l-menthol or salicylic acid ester as auxiliary agent.

Gel preparations for external application

A phamaceutical insertion composition comprising a mixture of an aqueous solution of carboxyvinyl polymer with a water-soluble basic compound and a pharmaceutical ingredient, said mixture being a gel having a pH value of from 4 to 10 and a viscosity of from 5,000 to 100,000 centipoises at 20.degree. C., which composition is applied to the rectal, vaginal or urethral tissue and the pharmaceutical ingredient is absorbed into the blood stream of the human body.

Pharmaceutical insertion compositions and a process for producing the

An anti-inflammatory, analgesic and anti-pruritic compositions for topical application is made by mixing an aqueous alcoholic solution of methanol or camphor with sufficient water soluble carboxyvinyl polymer to give a viscosity of 2,000 to 20,000 centipoises at 20.degree. C., sufficient basic agent, such as an amine, to neutralize the carboxyl groups to a pH of 6.0-7.5 and a small amount of sodium chloride.

Composition for topical application and method for preparing the same

A new type of preparation of clotrimazole, such as gel preparation, creamy preparation and liquid preparation, which are useful for an external use for the treatment of various trichophytoses, wherein the active clotrimazole is contained as being dissolved in crotamiton. Said new type of preparation of clotrimazole can be applied to the skin without drawbacks such as skin irritation and soiling of clothes as seen in the conventional tincture or ointments.

Novel preparation of clotrimazole

A creamy preparation containing a steroid compound having a pH of 4 to 7 and a viscosity of 10,000 to 100,000 centipoises, which is applicable to the skin and comprises a steroid compound (corticosteroids), a fluid oily substance, a nonionic surfactant, and an aqueous solution of carboxyvinyl polymer, said preparation having been neutralized with a basic substance, and a process for the preparation thereof. The creamy preparation has an excellent absorbability of the active steroid, excellent stability and excellent spreadability onto the skin and also good feeling in use.

Creamy preparation containing steroid and process for the preparation

A composition for a topical preparation which comprises a steroid, crotamiton, propylene glycol and a carboxyvinyl polymer in an aqueous medium, said composition having been neutralized with an organic amine, and a process for producing the same which comprises adding a mixed solution of crotamiton and propylene glycol containing a steroid to an aqueous solution of a carboxyvinyl polymer, followed by neutralizing the resultant solution with an organic amine while stirring, to give a transparent, gelatinous topical composition.

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Takatsuki, Japan

Takuzo Kamishita