Sankyo Company, Limited

Daiichi Sankyo Company, Limited

Ricoh Company, Ltd.

Takuya Uchida

Toshiyuki Konosu

Makoto Mori

Sadao Oida

Yoshiko Kagoshima

Yuko Yamamoto

Satoshi Ohya

Hiroshi Takeshita

Tsuyoshi Soneda

Junichi Kuroyanagi

Tetsunori Fujisawa

Aki Yokomizo

Nobuhisa Masuda

Issei Achiwa

Takafumi Hosokawa

Tetsuji Noguchi

Akihiko Nakagawa

Hideki Watanabe

Hiroyuki Moriya

Takahiro Shibayama

To develop an antibiotic having a novel mechanism of action, the present inventors have searched for a compound that has weak cytotoxicity, the physical property of high solubility in water, the effect of inhibiting both DNA gyrase GyrB and topoisomerase IV ParE subunits, and sufficient antibacterial activity. As a result, the present inventors have completed the present invention by finding that a compound of the present invention represented by the general formula (1), a pharmacologically acceptable salt thereof, and a prodrug thereof have desirable properties. The present invention provides a pharmaceutical composition (particularly, a preventive or therapeutic composition for infectious disease) comprising a compound represented by the formula (1), a pharmacologically acceptable salt thereof, or a prodrug thereof as an active ingredient.

Imidazole carbonyl compound

An antibiotic compound having a novel mechanism of action, weak cytotoxicity, high solubility in water, effective in inhibiting both DNA gyrase GyrB and topoisomerase IV ParE subunits, and having antibacterial activity.

A disclosed liquid container containing liquid to be supplied to a liquid discharge head includes a container main body defining a liquid containing section and including an opening section formed in one surface of the container main body, the opening section including an opening; and a film-like flexible member sealing the opening section of the container main body. Further, the film-like flexible member is joined with a joint section formed on the opening section of the container main body in a state where the film-like flexible member is bent, and a concave-convex structure is formed in the circumferential direction of the joint section.

Liquid container and image forming apparatus

A triazole compound of the formula (I) or a pharmacologically salt thereof: wherein X represents a group of formula X&#x2014;OH which has antifungal activity, L represents an -(adjacently substituted C-Caryl)-CHgroup and R represents a &#x2014;P(&#x2550;O)(OH)group.

Water-soluble triazole fungicide

Amide-type triazole compounds

Triazole derivatives having antifungal activity

Growing community of inventors

Tokyo, Japan

Takuya Uchida