Komatsu Corporation

Taisho Pharmaceutical Co., Ltd.

Takuya Takeda

Naoki Morimoto

Naoki Kojima

Richard J Roman

Noriyuki Miyata

Shingo Hidaka

Teisuke Takahashi

Hideki Tomoike

A tank mounted on a working vehicle is provided with an exterior member including a first plate unit, a second plate unit, a third plate unit, a fourth plate unit, a fifth plate unit, and a sixth plate unit, a first baffle plate joined to a first inner surface of the first plate unit, a second inner surface of the second plate unit, and a third inner surface of the third plate unit, and a second baffle plate joined to a fourth inner surface of the fourth plate unit, a fifth inner surface of the fifth plate unit, and a sixth inner surface of the sixth plate unit.

Tank and method of manufacturing tank

Medicaments that depend on a combination of SGLT 2 inhibitors and antihypertensive drugs and which are useful in the treatment of diseases involving at least hypertension or diabetes mellitus as a risk factor of cardiovascular events, as well as methods of treating the diseases are provided. Since the present invention exhibits a superior hypotensive action that cannot be attained by any single antihypertensive drugs, the conventional problems associated with the use of two or more antihypertensive drugs in order to lower the blood pressure to the desired level can be solved. In addition, the present invention shows a marked therapeutic efficacy in diabetes mellitus, a disease associated with diabetes mellitus, or complications of diabetes mellitus, in particular, diabetic nephropathy. As a further advantage, the present invention is also useful for the treatment of diseases involving lowered renal function.

Combinations of SGLT 2 inhibitors and antihypertensive drugs

A construction vehicle includes a cooling device. The cooling device includes a radiator disposed on a vehicle body frame, an oil cooler disposed adjacent to the radiator with a rear surface side thereof being arranged to face in roughly parallel to a lower part of a front surface of the radiator, and an opening/closing mechanism including a rotary shaft. The rotary shaft is obliquely disposed with a top end portion thereof being arranged closer to the front surface of the radiator than a bottom end portion thereof is. The opening/closing mechanism is configured to pivot the oil cooler about the rotary shaft and simultaneously move the oil cooler with respect to the radiator. Either a counterweight mounted on a rear part of the vehicle body frame or a part of the vehicle body frame is disposed on a line horizontally extended from a bottom end portion of the oil cooler.

Construction vehicle

Growing community of inventors

Tokyo, Japan

Takuya Takeda