Msd K.k.

Banyu Pharmaceutical Co. Ltd

Takuya Suga

Hiroyuki Takahashi

Norikazu Ohtake

Shigeru Tokita

Akio Kanatani

Norikazu Otake

Akio Ohno

Yuji Haga

Masanori Asai

Tomoharu Iino

Makoto Jitsuoka

Akira Naya

Ryo Yoshimoto

Hideki Jona

Hideaki Imamura

Etsuko Hirose

Disclosed are compounds of the following formula and their pharmaceutically-acceptable salts, which have an effect of glucokinase activation and are useful in the field of medicines for treatment for diabetes, obesity, etc. (wherein ring A represents a pyrazolyl group optionally having a lower alkyl group, etc.; ring B represents a heteroaryl group; R represents a lower alkyl group, etc.; Rrepresents a group of a formula: (wherein Rand Reach independently represent a hydrogen atom, etc.; m indicates an integer of from 2 to 6), etc.;Rrepresents a lower alkyl group, etc.; r indicates an integer of from 0 to 3; k indicates an integer of from 0 to 4).

Heteroaryl quinazoline derivatives

The present invention relates to compounds, which are useful for treatment and/or prevention of diabetes mellitus, diabetes mellitus complications or obesity, since the compounds have glucokinase-activating effects, and are presented in Formula (I): wherein Rrepresents a lower alkylsulfonyl group; Rrepresents a hydrogen atom; Rrepresents, e.g., a hydrogen atom; m represents an integer of from 1 to 3; and n represents zero or 1, or relates to a pharmaceutically acceptable salts thereof. 

Acetyl pyrrolidinyl indole derivative

Heteroaryloxy quinazoline derivative

Compounds of a formula (I) [wherein, A represents formula (III-1) R3 is a hydrogen, lower alkyl et al; m is 0 or 1; R1 is a hydrogen atom, halogen atom et al, R2 is a hydrogen et al; p is 0 to 4; X is a carbon atom or nitrogen atom; and X1 to X4 is a lower alkyl et al], or pharmaceutical acceptable salts thereof. These have a potency antagonistic to binding to histamine H3 receptor, or have a potency inhibiting the constant activity of histamine H3 receptor, and are useful in the therapy of obesity, diabetes et al.

Substituted pyridone derivative

Provided are compounds of a formula (I) and their pharmaceutically-acceptable salts: wherein X1, X2 and X3 each independently represent N or CH; W represents the following formula (II): or the following formula (III): Y represents a group of a formula (IV): The compounds have a histamine-H3 receptor antagonistic or inverse-agonistic activity and are useful for remedy and/or prevention of obesity, diabetes, hormone secretion disorders, sleep disorders, etc.

Heteroaryloxy nitrogenous saturated heterocyclic derivative

Compound of the formula: (I) [wherein each of X, Xand Xindependently represents N or CH, W represents the formula (II):(II) or the formula (III):(III) and Y represents a group of the formula (IV):(IV)], or a pharmacologically acceptable salt thereof. This compound exhibits histamine receptor H3 antagonist or inverse agonist activity and is useful of the treatment and/or prevention of obesity, diabetes, hormonal secretion abnormality, sleep, disorder, etc. 

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Tsukuba, Japan

Takuya Suga