Otsuka Pharmaceutical Company, Limited

Takuya Shitsuta

Noriaki Takemura

Hirofumi Sasaki

Naoto Utsumi

Hidetsugu Tsubouchi

Hideaki Kuroda

Shigekazu Fujita

Fumitaka Goto

Takeshi Hasegawa

Tadaaki Otani

Satoshi Yamada

Takashi Suzuki

Takashi Nakagawa

Nobuaki Ito

Kuninori Tai

Makoto Sakamoto

Seiji Akamatsu

Michinori Tanaka

Koichi Yasumura

Keizo Kan

Takumi Sumida

Yasuo Yanagihara

Yutaka Kojima

Keisuke Miyajima

Tae Fukushima

Kazuhisa Sugiyama

Hideki Takasu

Mitsuhiro Okuno

Naoto Ohi

Takeshi Kodama

Kunihiko Kiyono

Kenji Watanabe

Hitoshi Nagao

Hironori Tsutsui

Hideaki Satou

Shuji Matsumura

The present invention provides a novel compound, which has an excellent effect of suppressing the generation of collagen and less side effects, with being excellent in terms of safety. The compound of the present invention is represented by the following general formula (1): [wherein Xrepresents a nitrogen atom or a group &#x2014;CH&#x2550;; Rrepresents a group &#x2014;Z&#x2014;R, wherein Z represents a group &#x2014;CO&#x2014;, a group &#x2014;CH(OH)&#x2014;, or the like, and Rrepresents a 5- to 15-membered monocyclic, dicyclic, or tricyclic, saturated or unsaturated heterocyclic group having 1 to 4 nitrogen atoms, oxygen atoms, or sulfur atoms; Rrepresents a hydrogen atom, a halogen atom or a lower alkylene group; Y represents a group &#x2014;O&#x2014;, a group &#x2014;CO&#x2014;, a group &#x2014;CH(OH)&#x2014;, a lower alkylene group, or the like; and A represents a group or the like, wherein Rrepresents a hydrogen atom, a lower alkoxy group, or the like, p represents 1 or 2, and Rrepresents an imidazolyl lower alkyl group or the like.

Aromatic compounds for suppressing the generation of collagen

The present invention relates to a 1-substituted-4-nitroimidazole compound represented by the general formula (1) or a salt thereof, (wherein R is a hydrogen atom, a lower alkoxy group-substituted lower alkyl group, a phenyl-lower alkoxy group-substituted lower alkyl group, a cyano-substituted lower alkyl group, a phenyl-lower alkyl group which may have lower alkoxy groups as the substituents in the phenyl ring or a group of the formula &#x2014;CHR; X is a halogen atom or a group of the formula &#x2014;S(O)n-R) and method for preparing the same. The compound of the formula (1) is a useful compound as an intermediate for synthesis of various pharmaceutical and agricultural chemicals, particularly, as intermediates for antitubercular agents.

1-substituted-4-nitroimidazole compound and method for preparing the same

The present invention relates to a 1-substituted-4-nitroimidazole compound represented by the general formula (1) or a salt thereof, (wherein R is a hydrogen atom, a lower alkoxy group-substituted lower alkyl group, a phenyl-lower alkoxy group-substituted lower alkyl group, a cyano-substituted lower alkyl group, a phenyl-lower alkyl group which may have lower alkoxy groups as the substituents in the phenyl ring or a group of the formula &#x2014;CHR; X is a halogen atom or a group of the formula &#x2014;S(O)n&#x2014;R) and method for preparing the same. The compound of the formula (1) is a useful compound as an intermediate for synthesis of various pharmaceutical and agricultural chemicals, particularly, as intermediates for antitubercular agents.

1-substituted-4-nitroimidazole compound and process for producing the same

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Matsushige, Japan

Takuya Shitsuta