Japan Science and Technology Corporation

Keiichi Fukuda

Keio University

Takuya Shimazaki

Hideyuki Okano

Shinsuke Yuasa

Uichi Koshimizu

Keijiro Sugimura

Tomofumi Tanaka

Hayato Naka

For a method of inducing differentiation of cardiomyocytes from stem cells, a method is provided to induce efficiently and selectively differentiation of cardiomyocytes by such a method in which the stem cells are cultured to induce differentiation into cardiomyocytes in the presence of a substance that inhibits BMP signaling.

Method of inducing the differentiation of stem cells into myocardial cells

The present invention provides a method for producing motor neurons and GABAergic neurons characterized by including suspension-culturing embryonic stem cells in the presence or absence of a protein noggin to form embryoid bodies, selectively amplifying into neural stem cells from them by suspension culture in the presence of a fibroblast growth factor and a sonic hedgehog protein, and then differentiating the same. According to this method, at least motor neurons and GABAergic neurons can be systemically and efficiently produced from ES cells. Selective acquisition of neurons would be applicable to transplant therapy for amyotrophic lateral sclerosis, Huntington's chorea, Alzheimer's disease, etc.

Process for producing nerve stem cells, motor neurons, and GABAergic neurons from embryonic stem cells

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Tokyo, Japan

Takuya Shimazaki